Generation of human pluripotent stem cell lines (iPSCs) from mesenchymal stem cells (MSCs) from three elderly patients with osteoarthritis

Publication date: Available online 14 February 2020Source: Stem Cell ResearchAuthor(s): Lydiane Pichard, Jean-Marc Brondelo, Fabienne Becker, Romain Desprat, Frédéric De Ceuninck, Philippe Pastoureau, Danielle Noel, Christian Jorgensen, Jean-Marc LemaitreAbstractMesenchymal stem cells (MSCs) are a unique population of adult stem cells that can differentiate into many cell types. As such, MSCs represent an interesting source of stem cells for use in the clinical treatment of a variety of disorders involving tissue regeneration. It is therefore crucial to investigate further, whether MSCs from patients with bone or cartilage diseases are able to provide iPSCs lines with efficient differentiation ability into MSC derivatives. For this purpose, we derived 3 stable iPSC lines from the MSCs of 3 elderly patients with osteoarthritis (OA) able to re-differentiate into MSC to make bone, cartilage and adipose tissue.
Source: Stem Cell Research - Category: Stem Cells Source Type: research