Dual task in healthy elderly, depressive and Alzheimer’s disease patients

Conclusion The ability to perform two tasks simultaneously appears to be impaired in patients with Alzheimer ’ s disease, and unaffected by the major depressive disorder.RESUMO Objetivo Avaliar o quanto o desempenho em dupla tarefa pode ser afetado pelo diagn óstico do transtorno depressivo maior (TDM) e pela doença de Alzheimer (DA). Métodos Estudo de corte transversal com 108 indivíduos [Saudáveis (IS) = 56, TDM = 19, DA = 33] com 60 anos ou mais, de ambos os sexos, diagnosticados com doença de Alzheimer, transtorno depressivo maior e sem diagn óstico de doenças mentais, residentes na cidade do Rio de Janeiro. O desempenho em DT foi avaliado pela velocidade média (m/s), custo da dupla tarefa (CDT) e número de animais evocados por segundo (DTanimais). ANOVA one-way foi feita para a comparação dos grupos. Além disso, foi utilizada uma regressão logística para verificar a associação entre o desempenho nas variáveis em DT e o risco de TDM e DA, controlado pela idade e escolaridade. Resultados Houve diferença significativa entre os grupos IS e DA nas variáveis em DT. O pior desempenho no CDT e no número de animais evocado s em DT aumentou o risco de DA, independentemente da idade e escolaridade (CDT, OR = 5,6, IC de 95% = 1,4-22,2, p = 0,01 e DTanimals, OR = 3,6, IC de 95% = 0,97-14,0, p = 0,05). Conclusão A capacidade de...
Source: Jornal Brasileiro de Psiquiatria - Category: Psychiatry Source Type: research

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Abstract As the global population ages, the incidence of neurodegenerative diseases has risen. Furthermore, it has been suggested that depression, especially in elderly people, may also be an indication of latent neurodegeneration. Stroke, Alzheimer's disease (AD), and Parkinson's disease (PD) are usually accompanied by depression. The urgent challenge is further enforced by psychiatric comorbid conditions, particularly the feeling of despair in these patients. Fortunately, as our understanding of the neurobiological substrates of maladies affecting the central nervous system (CNS) has increased, more therapeutic ...
Source: Neural Plasticity - Category: Neurology Authors: Tags: Neural Plast Source Type: research
Purpose of review The present review aims to address the clinical benefits of using nicotinamide riboside, a precursor to the essential pyridine nucleotide, nicotinamide adenine dinucleotide (NAD+) as a therapeutic agent to attenuate age-related cognitive decline. Recent findings Oral supplementation with nicotinamide riboside can inhibit the accumulation of pathological hallmarks of Alzheimer's disease and improve learning and memory in various murine models for dementia. Nicotinamide riboside can also reduce DNA damage, neuroinflammation, apoptosis, and improved hippocampal synaptic plasticity in diabetic mice, and ...
Source: Current Opinion in Clinical Nutrition and Metabolic Care - Category: Nutrition Tags: MICRONUTRIENT SUPPLEMENTATION AND FUNCTIONAL FOODS: Edited by Nathalie M. Delzenne and Henry C. Lukaski Source Type: research
Conclusions. Compound 14b exhibited high affinity and excellent subtype selectivity, which was then evaluated by in vitro autoradiography and in vivo PET imaging study after labeling with carbon-11. Ligand [11C]14b, which we named [11C]MG2-1904, demonstrated high brain uptake and excellent in vitro/in vivo specific binding towards mGlu2 with high metabolic stability in the brain. As proof-of-concept, our preliminary work demonstrated a successful example of visualizing mGlu2 in vivo derived from NAMs, which represents a promising chemotype for further development and optimization aimed for clinical translation.
Source: Theranostics - Category: Molecular Biology Authors: Tags: Research Paper Source Type: research
Alzheimer's Society's new report,'Worst hit: dementia during coronavirus', says Government must fix social care now, learning lessons to avoid further winter tragedy, as dementia carers struggle with depression, insomnia and exhaustion. Since coronavirus (COVID-19) lockdown on 23 March, an Alzheimer's Society investigation has discovered family and friends have spent an extra 92 million hours caring for loved ones with dementia1, due to the double whammy of lockdown making dementia symptoms worse, and the chronically underfunded social care system leaving them nowhere else to turn.
Source: Current Awareness Service for Health (CASH) - Category: Consumer Health News Source Type: news
Growing evidence has shown that alterations in the gut microbiota composition were associated with a variety of neuropsychiatric conditions. However, whether such associations reflect causality remains unknown...
Source: Journal of Neuroinflammation - Category: Neurology Authors: Tags: Research Source Type: research
Abstract The brain endocannabinoid system has been shown to play a role in many physiological processes, including mood, learning and memory. It is also involved in the pathogenesis of anxiety, depression, mood disorders, as well as neurodegenerative disorders, although the exact mechanisms by which cannabinoid receptors interfere in these disorders are not well established. The aim of the present study was to evaluate the effects of cannabinoid ligands HU‑210 (CB1 receptor agonist) and SR 141716A (CB1 receptor antagonist) on learning and memory processes of rats with depressive - like state, induced by bilatera...
Source: Acta Neurobiologiae Experimentalis - Category: Neurology Authors: Tags: Acta Neurobiol Exp (Wars) Source Type: research
CONCLUSIONS: Our findings demonstrate little occurrence of olfactory hallucinations but that when they occur, they are experienced as relatively unpleasant in AD patients. Our findings also demonstrate a relationship between olfactory hallucinations and psychiatric characteristics (i.e., depression) in AD. PMID: 32981566 [PubMed - as supplied by publisher]
Source: Acta Neuropsychiatrica - Category: Psychiatry Tags: Acta Neuropsychiatr Source Type: research
Authors: Carty CL, Noonan C, Muller C, Saner D, Reiman EM, Buchwald D, Bell RA, Nelson LA Abstract The burden of Alzheimer's disease and related dementias (ADRD) has increased substantially in the United States, particularly in health disparity populations. Little is known about the epidemiology of ADRD in American Indian (AI) adults, although they have a high prevalence of ADRD risk factors including hypertension, diabetes, obesity, and smoking. Using electronic health records from a large health care organization during 2016-18, we describe characteristics of AI patients aged ≥55 years with and without an ADRD...
Source: Ethnicity and Disease - Category: International Medicine & Public Health Tags: Ethn Dis Source Type: research
Since the coronavirus (Covid-19) lockdown on 23rd March 2020, this investigation found family and friends have spent an extra 92 million hours caring for loved ones with dementia, due to the double impact of lockdown making dementia symptoms worse, and the chronically underfunded social care system leaving them nowhere else to turn. It states that the government must fix social care now, learning lessons to avoid further winter tragedy, as dementia carers struggle with depression, insomnia and exhaustion.
Source: Current Awareness Service for Health (CASH) - Category: Consumer Health News Source Type: news
CONCLUSION: Results of the study have shown that Turkish version of the MMCGI-SF was a reliable and valid tool to assess the pre-death reactions of adult offspring caregivers of AD. PMID: 32978955 [PubMed - in process]
Source: Turkish Journal of Psychiatry - Category: Psychiatry Authors: Tags: Turk Psikiyatri Derg Source Type: research
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