Tropheryma whipplei endocarditis: An uncommon infection with potentially fatal consequences

We report a case of culture ‐negative aortic valve endocarditis secondary toTropheryma whipplei infection. Our patient underwent aortic valve replacement after 4 weeks of antibiotic therapy with persistently negative blood culture results. Despite a technically uneventful operation, the patient showed continued sepsis and was unresponsive to a broad ‐spectrum of antibiotic therapy with subsequent multiorgan failure. He died on the 5th postoperative day, and diagnosis was established at postmortem examination. In this case report, we discuss the diagnosis and treatment of a rare type of endocarditis caused byT.whipplei.
Source: Journal of Cardiac Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: CASE REPORT Source Type: research

Related Links:

Abstract Infective endocarditis (IE) is a complex disease with cardiac involvement and multiorgan complications. Its prognosis depends on prompt diagnosis that leads to an aggressive therapeutic management combining antibiotic therapy and early cardiac surgery when indicated. However, IE diagnosis always poses a challenge, and echocardiography remains diagnostically imperfect in cases of prosthetic valve IE or cardiac implantable electronic device infection. In recent years, other imaging modalities (computed tomography, magnetic resonance imaging, nuclear imaging) have experienced significant technical improvemen...
Source: Circulation - Category: Cardiology Authors: Tags: Circulation Source Type: research
AbstractPurpose of ReviewThis discussion is intended to review the anatomy and pathology of the aortic valve and aortic root region, and to provide a basis for the understanding of and treatment of the important life-threatening diseases that affect the aortic valve.Recent FindingsThe most exciting recent finding is that less invasive methods are being developed to treat diseases of the aortic valve. There are no medical cures for aortic valve diseases. Until recently, open-heart surgery was the only effective method of treatment. Now percutaneous approaches to implant bioprosthetic valves into failed native or previously ...
Source: Current Cardiology Reports - Category: Cardiology Source Type: research
ConclusionThese two cases demonstrate that individualized long-term antibiotic suppressive therapy might be effective in selected patients with complicated PVE unfit or unwilling to undergo high-risk cardiothoracic surgical interventions.
Source: Infection - Category: Infectious Diseases Source Type: research
Cosmeri Rizzato1, Javier Torres2, Elena Kasamatsu3, Margarita Camorlinga-Ponce2, Maria Mercedes Bravo4, Federico Canzian5 and Ikuko Kato6* 1Department of Translation Research and of New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy 2Unidad de Investigación en Enfermedades Infecciosas, Unidades Médicas de Alta Especialidad Pediatría, Instituto Mexicano del Seguro Social, Mexico City, Mexico 3Instituto de Investigaciones en Ciencias de la Salud, National University of Asunción, Asunción, Paraguay 4Grupo de Investigación en Biología del C&aacut...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
AbstractInfective endocarditis (IE) is associated with significant serious adverse outcomes including death. IE usually presents with diverse clinical picture and syndromic diagnoses including heart failure, stroke, and peripheral embolization. Given variable, vague, and syndromic presentations, the diagnosis of IE may be delayed for days to weeks. Maintaining a high index of suspicion among clinicians is the key to early recognition of the disease and prompt initiation of antimicrobial therapy to prevent IE-associated mortality and morbidity. Blood culture and echocardiography remain essential tools in the diagnosis of in...
Source: Current Treatment Options in Cardiovascular Medicine - Category: Cardiology Source Type: research
Coxiella burnetii is a common cause of blood culture–negative infective endocarditis (IE). Molecular detection of C burnetii DNA in clinical specimens is a promising method of diagnosing Q fever endocarditis. Here, we examined the diagnostic utility of Q fever polymerase chain reaction (PCR) of formalin-fixed heart valve tissue from patients with blood culture–negative IE who underwent heart valve surgery. Clinical and laboratory data of patients with blood culture–negative IE who underwent heart valve surgery during a 6-year period and for whom biopsy tissues were available were reviewed retrospectively....
Source: Medicine - Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research
We present various echocardiograms which closely follow the progression the infective endocarditis in a patient with previous cardiac surgery and prosthetic material in situ.A 51 year old gentleman presented presented with complaints of fevers and gastrointestinal infective symptoms in the context of previously having undergone an aortic root replacement and metallic aortic valve implantation several years prior for a previous episode of aortic dissection whilst utilising illicit intravenous drug use.Echocardiography noted an aortic valve vegetation and blood cultures grew non typhoidal Salmonella Typhimurium. A surgi...
Source: Journal of Indian College of Cardiology - Category: Cardiology Source Type: research
We describe the case of a 71-year-old man suffering from liver cirrhosis with an acute purulent pericarditis. The organism responsible for his pericarditis was Clostridium septicum; a Gram-positive obligatory pathogen, commonly associated with gastrointestinal tumours. Despite the prolonged, targeted antibiotic therapy, the infection resulted in endocarditis and the need for an urgent the aortic valve replacement.
Source: Cor et Vasa - Category: Cardiology Source Type: research
We present various echocardiograms which closely follow the progression the infective endocarditis in a patient with previous cardiac surgery and prosthetic material in situ.A 51 year old gentleman presented presented with complaints of fevers and gastrointestinal infective symptoms in the context of previously having undergone an aortic root replacement and metallic aortic valve implantation several years prior for a previous episode of aortic dissection whilst utilising illicit intravenous drug use.Echocardiography noted an aortic valve vegetation and blood cultures grew non typhoidal Salmonella Typhimurium. A surgi...
Source: Journal of Indian College of Cardiology - Category: Cardiology Source Type: research
We describe the case of a 71-year-old man suffering from liver cirrhosis with an acute purulent pericarditis. The organism responsible for his pericarditis was Clostridium septicum; a Gram-positive obligatory pathogen, commonly associated with gastrointestinal tumours. Despite the prolonged, targeted antibiotic therapy, the infection resulted in endocarditis and the need for an urgent the aortic valve replacement.
Source: Cor et Vasa - Category: Cardiology Source Type: research
More News: Antibiotic Therapy | Cardiovascular & Thoracic Surgery | Endocarditis | Heart Valve Surgery