IVF Video : Self Inflicted Infertility
Many papers and reviews have described the changes of the cervix during pregnancy, cervical cancer, sexually transmitted infections, and cervicovaginal microbiota. In this Views and Reviews, we focus on some specific topics in relation to the uterine cervix and infertility: early cervical cancer and fertility sparing surgery, cesarean scar defect, cervical incompetence, and cervical m üllerian anomalies.
Around 20% of pregnant women undergo cesarean section (CS), and in most regions of the world CS rates continue to grow. There is still no clear definition of what is considered a normal physiologic aspect of a CS scar and what is abnormal. Cesarean scar defects (CSDs) should be suspected in women presenting with spotting, dysmenorrhea, pelvic pain, or infertility and a history of CS. CSDs can be visualized with the use of hysterosalpingography, transvaginal sonography, saline infusion sonohysterography, hysteroscopy, and magnetic resonance imaging.
Conclusion: HIFU showed a safe and effective profile as a therapeutic management option for patients with adenomyosis. In comparison with LE, HIFU treatment achieved better postoperative reproductive outcomes. HIFU treatment should be encouraged and implemented in clinical practice. PMID: 32208771 [PubMed - in process]
Conclusions: CEP290 mutations are associated with a variety of overlapping clinical phenotypes, some of which will become better understood as more patients with these conditions survive to reproductive age. Similarly, increased understanding of the molecular mechanisms that underlie differences in phenotype may provide avenues to consider in future therapies. PMID: 32208788 [PubMed - as supplied by publisher]
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ConclusionOur simple evidence-based nomogram presents graphically risk factors and prognostic models for IVF/ICSI outcomes in patients with PCOS, which can offer useful guidance to clinicians and patients for individual adjuvant therapy.
I was diagnosed with anorexia nervosa over a decade ago. Blinded by the eating disorder to the damage that was occurring both internally and externally, the possibility of infertility did not occur to me. When I married at 21, my husband and I both dreamed of one day becoming parents and I lived in this optimism for some time. However, after my periods stopped for 7 years, I began to doubt if being a mother would ever be my reality. As an eating disorder patient, I had been regularly informed of the risk factors of my illness, some of which included amenorrhoea, the absence of menstruation, and a high chance of infer...
ConclusionOur findings show that the bioinformatics tool HipSTR is 100% accurate in detecting and assessingAR CAG repeats in infertile men (46,XY) as well as in men with low ‐level mosaicism.
(University of Pennsylvania) Researchers led by Jeremy Wang of the University of Pennsylvania School of Veterinary Medicine have identified an enzyme essential for the process of male meiosis, the type of cell division that produces sperm. The protein, SKP1, controls one of the key transitions in meiosis. Understanding its role may help scientists develop new approaches to treating male infertility.
Abstract To compare the ovarian responses after administration of two recombinant follicle-stimulating hormone (r-FSH) preparations under gonadotropin-releasing hormone (GnRH) analogue downregulation, we conducted a phase 3, randomized, multicenter, assessor-blind, active-controlled, parallel group study. The primary outcome was the number of oocytes retrieved. The secondary outcomes included total dose and duration of r-FSH administered, oocyte quality, blood estradiol levels, follicular development, fertilization rates, implantation rates, and pregnancy rates (biochemical, clinical, and ongoing). A total of 451 ...