Acute stress-induced coagulation activation in patients with remitted major depression versus healthy controls and the role of stress-specific coping - von K änel R, Merz F, Pfister H, Brückl T, Zimmermann P, Uhr M, Holsboer F, Höhne N, Ising M.

We examined ...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Ergonomics, Human Factors, Anthropometrics, Physiology Source Type: news

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Depression affects about 20% of Americans in their lifetime, and is one of the leading causes of disability. The rates of depression are even higher in those with cardiovascular disease (CVD). Depression affects 38% of patients undergoing coronary artery bypass graft surgery, and the risk of depression is three times as high in patients who have experienced a heart attack compared with the general population. Depression also makes it much more likely that CVD patients will be readmitted to the hospital and report heart-related symptoms. Yet much of the time, symptoms of depression in those with CVD go unrecognized. And as ...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Anxiety and Depression Health Heart Health Source Type: blogs
This study aims to develop an understanding of the s exual health experiences of Italian women 1 year after they experienced AMIs. This qualitative study used Cohen’s phenomenological design. A sample of 12 women was interviewed. Each interview was audio-recorded, and all interviews had a duration ranging from 40 to 60 min. Interviews were read, r e-read, and analyzed by each researcher, who then extrapolated themes. Three main themes emerged from the analysis of the interviews: the fear of a recurring infarction, stress, and the desire to receive information about their recovery. Two sub-themes also emerge...
Source: Sexuality and Disability - Category: Disability Source Type: research
Early ECG change in transmural MI – MCQ Early ECG change in transmural myocardial infarction: a) ST depression in the leads facing the infarct b) ST elevation in the leads facing the infarct c) Q waves in the leads oriented to the infarct d) T inversion in leads oriented to the infarct Post your answer as a comment below
Source: Cardiophile MD - Category: Cardiology Authors: Tags: Medicine MCQ - CVS Source Type: blogs
Artificial intelligence does wonders in healthcare. The technology helped issue the first COVID-19 warning before the WHO and CDC did so. It can slash the phenomenon of alarm fatigue. IBM’s Watson Health leverages the power of A.I. to bring drugs to the market faster. And it does so while cutting costs by over 50%. Speaking of IBM Watson, while the algorithm got its name from the company’s founder Thomas J. Watson, there’s another pop culture figure attached to that name. It’s elementary; we’re talking about none other than Sherlock Holmes’ sidekick, Dr. Watson. It seems like real-wor...
Source: The Medical Futurist - Category: Information Technology Authors: Tags: Artificial Intelligence AI digital health Healthcare Medicine technology Source Type: blogs
Stress caused by uncertainty can be paralyzing. The information we are getting about the coronavirus seems to be changing by the hour — creating unprecedented uncertainty. There is a good reason your nerves are jangle, or you are feeling unsettled or anxious. Uncertainty is perceived as unsafe and potentially painful. Whether the situation is predictably positive or predictably negative, your brain prefers something familiar to something unfamiliar. Under stress, our brains depend on instinct rather than rational thought because the part of the brain responsible for critical thinking is busy dealing with the psycholo...
Source: Embrace Your Heart Wellness Initiative - Category: Cardiology Authors: Tags: Stress Management uncertainty Source Type: blogs
While at work, one my partners showed me this ECG of a 50-something woman with abdominal pain associated with alcohol withdrawal and alcoholic ketoacidosis.  There was no reported chest pain or SOB.What do you think?I said it " looks like takotsubo.  Electrolytes might contribute.  Are they back yet? (they were not).  I do not think this is a coronary event. "He asked why.I responded: " bizarre T-waves, with T-wave inversion and extremely long QT.  The computer measures the QT at 506 ms, but it really is more like 560-580 ms, with a QTc of 600-620 ms.  This is not at all typical...
Source: Dr. Smith's ECG Blog - Category: Cardiology Authors: Source Type: blogs
ConclusionsSTE-aVR with multilead ST depression was associated with acutely thrombotic coronary occlusion in only 10% of patients. Routine STEMI activation in STE-aVR for emergent revascularization is not warranted, although urgent, rather than emergent, catheterization appears to be important.Previously, Knotts et al. had published different, but also convincing, data:Knotts et al. found that such ECG findings (STE in aVR) only represented left main ACS in 14% of such ECGs: Only 23% of patients with the aVR STE pattern had any LM disease (fewer if defined as  ≥ 50% stenosis). Onl...
Source: Dr. Smith's ECG Blog - Category: Cardiology Authors: Source Type: blogs
In this study, we investigated the function of miR-665 in MI. In the present study, an ischemia/reperfusion (I/R) rat model and a hypoxia/reoxygenation (H/R)-induced H9c2 cell model were successfully established to mimic the MI for in vivo and in vitro studies. The concentrations of lactate dehydrogenase (LDH), creatine kinase-MB (CK-MB), tumor necrosis factor alpha (TNF-α), IL-6, and reactive oxygen species (ROS) were then measured. Moreover, cell viability and apoptosis were detected by MTT assay, TdT-mediated dUTP nick end labeling (TUNEL), and PI/FITC-annexin V assay. The binding of miR-665 and Pak1 was determine...
Source: International Heart Journal - Category: Cardiology Tags: Int Heart J Source Type: research
Purpose The purpose of this study was to assess the possible relation between use of antidepressant (AD) drugs, that is, tricyclic ADs, selective serotonin reuptake inhibitors (SSRIs), and atypical ADs (AAs), and the risk of hospitalization for cardiovascular (CV) events among older patients with previous CV diseases. Methods A nested case-control study was carried out among patients aged 65 years and older from 5 Italian health care territorial units who were discharged for CV disease during 2008 to 2010. The cohort was composed by 344,747 individuals, and of these, 97,739 (28%) experienced hospital admission for CV ...
Source: Journal of Clinical Psychopharmacology - Category: Psychiatry Tags: Original Contributions Source Type: research
In this study, we investigated the role of M1-like macrophage-derived exosomes in a MI microenvironment. We found that the proinflammatory M1-like-type macrophages released an extensive array of proinflammatory exosomes (M1-Exos) after MI. M1-Exos exerted an anti-angiogenic effect and accelerated MI injury. They also exhibited highly expressed proinflammatory miRNAs, such as miR-155. miR-155 was transferred to endothelial cells (ECs), leading to the inhibition of angiogenesis and cardiac dysfunction by downregulating its novel target genes, including Rac family small GTPase 1 (RAC1), p21 (RAC1)-activated kinase 2 (PAK2), S...
Source: Basic Research in Cardiology - Category: Cardiology Source Type: research
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