Inhibition of Bacterial Biofilm Formation by Phytotherapeutics with Focus on Overcoming Antimicrobial Resistance.

Inhibition of Bacterial Biofilm Formation by Phytotherapeutics with Focus on Overcoming Antimicrobial Resistance. Curr Pharm Des. 2020 Feb 12;: Authors: Janga YS, Mosolygó T Abstract Bacteria within biofilms are more resistant to antibiotics and chemical agents than planktonic bacteria in suspension. Treatment of biofilm-associated infections inevitably involves high dosages and prolonged courses of antimicrobial agents; therefore, there is a potential risk of the development of antimicrobial resistance (AMR). Due to the high prevalence of AMR and its association with biofilm formation, investigation of more effective anti-biofilm agents is required. From ancient times, herbs and spices have been used to preserve foods, and their antimicrobial, anti-biofilm and anti-quorum sensing properties are well known. Moreover, phytochemicals exert their anti-biofilm properties at sub-inhibitory concentrations without providing the opportunity for the emergence of resistant bacteria or harming the host microbiota. With increasing scientific attention to natural phytotherapeutic agents, numerous experimental investigations have been conducted in recent years. The present paper aims to review the articles published in the last decade in order to summarize a) our current understanding of AMR in correlation with biofilm formation and b) the evidence of phytotherapeutic agents against bacterial biofilms and their mechanisms of action. The main focus has been put ...
Source: Current Pharmaceutical Design - Category: Drugs & Pharmacology Authors: Tags: Curr Pharm Des Source Type: research

Related Links:

Publication date: Available online 4 April 2020Source: Journal of Orthopaedic TranslationAuthor(s): Zeqing Huang, Fanyu Fu, Hengli Ye, Huanhuan Gao, Biao Tan, Rongtian Wang, Na Lin, Ling Qin, Weiheng Chen
Source: Journal of Orthopaedic Translation - Category: Orthopaedics Source Type: research
Publication date: Available online 4 April 2020Source: Journal of EthnopharmacologyAuthor(s): Jian-Mei Li, Yue Zhao, Yang Sun, Ling-Dong Kong
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
Conclusion: Gut microbiota composition and function are associated with CKD severity. And, specific gut microbes are potentially helpful for CKD early diagnosis and prognosis monitoring. PMID: 32241215 [PubMed - as supplied by publisher]
Source: Postgraduate Medicine - Category: Internal Medicine Tags: Postgrad Med Source Type: research
Authors: Bassetti M, Del Puente F, Magnasco L, Giacobbe DR Abstract Introduction: Methicillin-resistant Staphylococcus aureus (MRSA) is among the most frequent causative agents of acute bacterial skin and skin-structure infections (ABSSSI) and has been associated with increased risks of invasive disease and of treatment failure.Areas covered: In this review, we focus on those novel anti-MRSA agents currently in phase I or II of clinical development that may enrich the armamentarium against ABSSSI caused by MRSA in the future.Expert opinion: Promising agents belonging to either old or novel antibiotic classes are cu...
Source: Expert Opinion on Investigational Drugs - Category: Drugs & Pharmacology Tags: Expert Opin Investig Drugs Source Type: research
Publication date: June 2020Source: Journal of Global Antimicrobial Resistance, Volume 21Author(s): Marisa Haenni, Farid El Garch, Christine Miossec, Jean-Yves Madec, Didier Hocquet, Benoit Valot
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
Publication date: Available online 3 April 2020Source: Journal of Global Antimicrobial ResistanceAuthor(s): Sana Dhaouadi, Leila Soufi, Amani Hamza, Didier Fedida, Chtioui Zied, Emna Awadhi, Mohamed Mtibaa, Bilel Hassen, Ameur Cherif, Carmen Torres, Mohamed Salah Abbassi, Ramzi Boubaker Landolsi
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
Publication date: Available online 3 April 2020Source: Journal of Global Antimicrobial ResistanceAuthor(s): Absar Talat, Shamsi Khalid, Hayder Abdul R Majeed, Asad U. Khan
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
Publication date: Available online 3 April 2020Source: Journal of Global Antimicrobial ResistanceAuthor(s): A.F.A.D. Schauwvlieghe, R.G.M. Bredius, Rob M. Verdijk, Frans J.W. Smiers, Martha T. van der Beek, Bianca F. Goemans, C. Michel Zwaan, Roger J. Brüggemann, Bart J.A. Rijnders
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
Conclusion This study confirms the in vitro antibacterial activity of BIOCITRO® against Gram-negative and Gram-positive bacteria. For most of the strains, the product reached the bactericidal effect at the same concentration of the bacteriostatic effect and maximum difference between MIC and MBC was two dilution steps. The less susceptible species of the study were S. enterica ssp. enterica and E. coli with MBC90 values of 256 and 128 μg/mL, respectively, while the most susceptible was C. perfringens with MBC90 of 16 μg/mL. After short exposition time to the product, the significant effect over the viability of ...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Conclusion Genomic analyses herein performed allowed us to confirm the recently (Pérez-Cataluña et al., 2018a,b) suggested amendment of A. butzleri as Al. butzlerii, comb. nov. Antimicrobial susceptibility tests defined Ab 55 and Ab 6V strains as resistant to vancomycin, tetracyclin, nalidixic acid (only Ab 55 whereas Ab 6V is intermediate resistant), erythromycin, and β-lactam antibiotics. Moreover, in our strains isolated from shellfish, we identified numerous virulence, antibiotic, and heavy metal resistance determinants, also additional to those previously found in the genome sequenced A. butzleri ...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
More News: Antimicrobial Resistance | Campylobacter | Chemistry | Complementary Medicine | Drugs & Pharmacology | Gastroenteritis | Herbs | Listeria | Salmonella | Staphylococcus Aureus