Ring analysis of multifocal oscillatory potentials (mfOPs) in cCSNB suggests near-normal ON –OFF pathways at the fovea only

AbstractPurposeTo investigate the center-periphery distribution of ON and OFF retinal responses in complete congenital stationary night blindness (cCSNB).MethodsPhotopic full-field flash ERGs (photopic ffERGs) and OPs (photopic ffOPs) and slowm-sequence (to enhance OP prominence) mfERGs (and filtered mfOPs) evoked by a 37 hexagon stimulus array were recorded from normal subjects and cCSNB patients. Discrete wavelet transform (DWT) analysis of photopic ffERGs and mfERGs was also performed in order to assess the contribution of the ON and OFF retinal pathways (i.e., OFF-to-ON ratio) in both cohorts.ResultsAs expected, the photopic ffERG (and ffOPs) responses in cCSNB were devoid of the first two of the three OPs (i.e., OP2 and OP3 and OP4) normally seen on the ascending limb of theb-wave. A similar finding was also noted in the mfERGs (and mfOPs) of ring 4. In contrast, the mfERGs (and mfOPs) of ring 1 included all three OPs. DWT analysis revealed that while in normal subjects, the OFF-to-ON ratio of mfERGs slightly increased from rings 1 to 4 (from 0.61  ± 0.03 to 0.78 ± 0.04;p 
Source: Documenta Ophthalmologica - Category: Opthalmology Source Type: research

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