GRP78 antibodies is associated with blood ‐brain barrier breakdown in paraneoplastic cerebellar degeneration in Lambert‐Eaton myasthenic syndrome

AbstractLambert ‐Eaton myasthenic syndrome (LEMS) is an autoimmune neuromuscular junction disease associated with P/Q‐type voltage‐gated calcium channels (P/Q‐type VGCCs) autoantibodies1. P/Q ‐type VGCCs present at the presynaptic motor nerve terminals and their antibodies induce a reduction in neurotransmitter release, leading to the characteristic muscle weakness associated with the disease. Approximately half of LEMS patients have small‐cell lung carcinoma (SCLC) that occurs as a paraneoplastic disorder.
Source: Clinical and Experimental Neuroimmunology - Category: Neurology Authors: Tags: NEW DEVELOPMENTS IN NEUROIMMUNOLOGY Source Type: research