Good long-term outcomes in patients with Primary Sclerosing Cholangitis undergoing living donor liver transplantation
ConclusionLDLT can be performed in PSC with good overall long-term outcomes.
Consultations in Liver Disease
Vinod K. Rustgi
NORMAN GITLIN, MD, FRCP (LONDON), FRCPE (EDINBURGH), FAASLD, FACP, FACG
CLINICS IN LIVER DISEASE
Hippocrates (460-371 bc) first recognized the relationship between the neuropsychological and physiologic changes observed in liver disease (Figs. 1 and 2). At that time, Hippocrates noted that there was a poor clinical outcome associated with delirium that was preceded by jaundice.1
Contributors : Michele Vacca ; Antonio Vidal-Puig ; Brian Y Lam ; Marcella MaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTGF β/BMP family member Bone Morphogenetic Protein 8b (Bmp8b) is upregulated in NASH (Western Diet -WD- Model), acute liver damage (CCl4 model) and by Partial Hepatectomy (PH). Absence of Bmp8b reduces liver inflammation and fibrosis in the NASH model (WD). In the acute (3days) CCl4 model, absence of B mp8b impacts acute inflammatory responses, hepatic stellate cells (HSC) activation, and compensatory hepatocyte proliferation; defective inflammatory pathway...
Contributors : Christine Yu ; Kaoru Hida ; Efstathia PapafragkouSeries Type : Expression profiling by genome tiling arrayOrganism : Allium fistulosum ; Apium graveolens ; Astrovirus sp. ; Bacillus subtilis ; Coxsackievirus ; Hepatitis E virus ; Hepatovirus A ; Norovirus ; Rotavirus ; Sapovirus ; Solanum lycopersicum ; unidentified adenovirusThe capability of the U.S. Food and Drug Administration Enteric Viruses tiling microarray (FDA-EVIR) was assessed for rapid molecular identification of human norovirus (NoV) and hepatitis A virus (HAV) extracted from artificially inoculated fresh produce. Two published viral extraction ...
Contributors : Elizabeth Ostrander ; Grant A ChallenSeries Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusEpigenetic modifying enzymes DNMT3A and TET2 are recurrently mutated in hematological disorders despite possessing opposing biochemical functions in the DNA methylation processes. Using conditional ablation, we show these contrasting genotypes result in different functional effects in hematopoietic stem cells (HSCs). Loss of Dnmt3a bestows enhanced self-renewal on HSCs in serial, competitive repopulation assays while Tet...
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