Differential Impact of Insulin Sensitizers vs. Anti-Androgen on Serum Leptin Levels in Vitamin D Replete PCOS Women: A Six Month Open Labeled Randomized Study
Horm Metab Res 2020; 52: 89-94 DOI: 10.1055/a-1084-5441Women with PCOS are linked to insulin resistance, inflammation, and vitamin D
(VD) deficiency. The study endeavors to comprehend the differential impact
of insulin sensitizers vs. anti-androgen on serum leptin levels among women
with PCOS rendered vitamin D replete with high VD oral supplement. This was
open-labeled randomized study that screened 180 eligible women presenting to
Endocrine clinic with oligomenorrhea or features of hyperandrogenism.
Ninety-nine women who furnished written informed consent and fulfilled the
Rotterdam 2003 criteria for diagnosis of PCOS were randomized into 3 drug
treatment arms to receive either spironolactone (50 mg/d;
n=30), metformin (1000 mg/d; n=30) or
pioglitazone (30 mg/d; n=30). These women were also
administered oral VD (4000 IU/day) in addition to the allocated drug
for a period of 6 months. Detailed history, clinical examination, and
laboratory evaluation was carried out at baseline and 6 months after
intervention. Number of menstrual cycles/year increased while as
Ferriman–Gallwey score, blood glucose, HOMA-IR, and plasma insulin
levels significantly decreased in all the three arms with better outcomes in
spironolactone and pioglitazone arms (p<0.05). Similarly, serum
leptin levels superiorly improved in spironolactone and pioglitazone group.
Pioglitazone group showed better efficacy in lowering serum total
testosterone (p<0.05). Co-supplementation of high dosage VD...
Source: Hormone and Metabolic Research - Category: Endocrinology Authors: Rashid, Aafia Ganie, Mohd Ashraf Wani, Imtiyaz Ahmad Bhat, Gulzar Ahmad Shaheen, Feroz Wani, Ishfaq Ahmed Shrivastava, Mukesh Shah, Zaffar Amin Tags: Endocrine Care Source Type: research
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