Expression of Receptor Tyrosine Kinases on Peripheral Blood Mononuclear Cells and Tumor-Infiltrating Lymphocytes in Patients with Renal Cell Carcinoma and Healthy Donors.

CONCLUSIONS: PBMC and TIL had similar low RTK expression levels in RCC patients. PBMC of healthy humans had a significantly higher expression of RTK. PD-L1 and PDGFRα-β expression could correlate. Comprehensive basic and clinical studies will be needed to define a biological role of RTKs on different lymphocyte subsets and correlations between clinical outcomes and expression levels. PMID: 32053815 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/32053815?dopt=Abstract

Source: Oncology - February 12, 2020 Category: Cancer & Oncology Authors: Tsimafeyeu I, Volkova M, Olshanskaia A, Raskin G, Aschuba S, Khochenkova Y, Bondarenko A, Khochenkov D Tags: Oncology Source Type: research