Oseltamivir for All: Should It Become an Over ‐the‐Counter Medication for Influenza Treatment?

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, EarlyView.
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - Category: Drugs & Pharmacology Authors: Tags: Editorial Source Type: research

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AbstractIn 2014, our research network was involved in the evaluation of favipiravir, an anti ‐Influenza polymerase inhibitor, against Ebola virus. In this review we discuss how mathematical modelling was used, first to propose a relevant dosing regimen in humans, and then to optimize its antiviral efficacy in a non‐human primate (NHP) model. The data collected in NHPs were finally used to develop a model of Ebola pathogenesis integrating the interactions between the virus, the innate and adaptive immune response and the action of favipiravir. We conclude the review of this work by discussing how these results are of re...
Source: CPT: Pharmacometrics and Systems Pharmacology - Category: Drugs & Pharmacology Authors: Tags: REVIEW ARTICLE Source Type: research
Publication date: Available online 29 March 2020Source: Antiviral ResearchAuthor(s): Núria Soldevila, Diana Toledo, Raúl Ortiz de Lejarazu, Sonia Tamames, Jesús Castilla, Jenaro Astray, Maria Amelia Fernández, Vicente Martín, Mikel Egurrola, María Morales Suárez-Varela, Àngela Domínguez, J.M. Mayoral, J. Díaz-Borrego, A. Morillo, M.J. Pérez-Lozano, J. Gutiérrez, M. Pérez-Ruiz, M.A. Fernández-Sierra, S. Tamames, S. Rojo-Rello
Source: Antiviral Therapy - Category: Virology Source Type: research
Conditions:   COVID-19;   Coronavirus Infections;   Hay Fever;   Asthma;   Chronic Obstructive Pulmonary Disease;   Influenza;   Common Cold;   Respiratory Tract Infections;   Healthy Intervention:   Sponsor:   HealthMode Inc. Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Asian locales reacted swiftly to the threat of COVID-19 by leveraging lessons learned from previous pandemics and making use of serology testing in aggressive contact tracing America’s healthcare leaders in government, hospitals, clinical pathology, and medical laboratories can learn important lessons from the swift responses to the early outbreaks of COVID-19 in countries like Taiwan […]
Source: Dark Daily - Category: Laboratory Medicine Authors: Tags: Instruments & Equipment International Laboratory News Laboratory Instruments & Laboratory Equipment Laboratory Operations Laboratory Pathology Management & Operations anatomic pathology avian influenza CDC centers for disease control and Source Type: news
Ajay Kohli Vinay Kohli Chitra Chhabra Kohli By CHITRA CHHABRA KOHLI MD, AJAY KOHLI MD, and VINAY KOHLI MD, MBA With a doubling time of cases estimated between 3 days within the U.S. and about 6 days globally (at the time of this writing) COVID-19 is demonstrating its terrifying virulence as it spreads across the world. What’s perhaps equally terrifying, if not more, is the absence of a known cure or treatment plan for COVID-19. While there has been a lot of attention focused on Hydroxychloroquine and Azithromycin, there has been debate on the scientific validity of these treatment options, either as t...
Source: The Health Care Blog - Category: Consumer Health News Authors: Tags: COVID-19 Patients Physicians Ajay Kohli Azithromycin convalescent plasma therapy coronavirus COVID-19 treatment hydroxychloroquine Pandemic Vinay Kohli Source Type: blogs
Publication date: Available online 29 March 2020Source: American Journal of Infection ControlAuthor(s): Christopher Blank, Nancy Gemeinhart, W. Claiborne Dunagan, Hilary M. Babcock
Source: American Journal of Infection Control - Category: Infectious Diseases Source Type: research
(Forschungsverbund Berlin) Hope of new therapeutic options for suppressing seasonal influenza and avian flu: On the basis of an empty -- and therefore non-infectious -- shell of a phage virus, researchers from Berlin have developed a chemically modified phage capsid that " stifles " influenza viruses. The results are also being used for the immediate investigation of the coronavirus.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
ConclusionsPBB is common in male infants with chronic wet cough and accompanied by wheezing and airway deformities. Most cases are clinically diagnosed PBB in China and microbiologically-based-PBB is common in western countries. Co-infection could be found,Streptococcus pneumoniae andHaemophilus influenza were the most frequent etiology in China and western countries, respectively. Patients with comorbidities may need extended antibiotics treatment for more than 2 weeks.
Source: Italian Journal of Pediatrics - Category: Pediatrics Source Type: research
a Poromov Free radical reactions play an important role in biological functions of living systems. The balance between oxidants and antioxidants is necessary for the normal homeostasis of cells and organisms. Experimental works demonstrate the role of oxidative stress that is caused by influenza virus as well as the toxic effects of some antiviral drugs. Therefore, antiviral drugs should be characterized by its pro- and antioxidant activity, because it can affect its therapeutic efficiency. The aim of the study was to quantify the antioxidant capacity and propose the mechanism of the antioxidant effect of the antivi...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
There no firm proof that gargling prevents respiratory infections caused by coronavirus — or any virus or bacteria. But there’s also little downside.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Colds Iodine Coronavirus (2019-nCoV) Throat Influenza Microbiology Mouthwash Hygiene and Cleanliness Source Type: news
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