Toll-like receptors in mediating the pathogenesis in Systemic Sclerosis.

We report the new DAMPs, as well as the TLR-linked pathways involved in disease, with emphasis on Type I interferon signature in SSc, the role of plasmacytoid dendritic cells (pDCs) and platelets. The dissection of the contribution of all these pathways to disease, and their correlation with the disease status, as well as their values as prognostic tools, can help to plan timely intervention and design new drugs for more appropriate therapeutic strategies.
PMID: 32048277 [PubMed - as supplied by publisher]

Source: Clinical and Developmental Immunology - February 10, 2020 Category: Allergy & Immunology Authors: Frasca L, Lande R Tags: Clin Exp Immunol Source Type: research