Neoantigens in Hematologic Malignancies

T cell cancer neoantigens are created from peptides derived from cancer-specific aberrant proteins, such as mutated and fusion proteins, presented in complex with human leukocyte antigens on the cancer cell surface. Because expression of the aberrant target protein is exclusive to malignant cells, immunotherapy directed against neoantigens should avoid “on-target, off-tumor” toxicity. The efficacy of neoantigen vaccines in melanoma and glioblastoma and of adoptive transfer of neoantigen-specific T cells in epithelial tumors indicates that neoantigens are valid therapeutic targets. Improvements in sequencing technology and innovations in antigen discovery approaches have facilitated the identification of neoantigens. In comparison to many solid tumors, hematologic malignancies have few mutations and thus fewer potential neoantigens. Despite this, neoantigens have been identified in a wide variety of hematologic malignancies. These include mutated nucleophosmin1 and PML-RARA in acute myeloid leukemia, ETV6-RUNX1 fusions and other mutated proteins in acute lymphoblastic leukemia, BCR-ABL1 fusions in chronic myeloid leukemia, driver mutations in myeloproliferative neoplasms, immunoglobulins in lymphomas, and proteins derived from patient-specific mutations in chronic lymphoid leukemias. We will review advances in the field of neoantigen discovery, describe the spectrum of identified neoantigens in hematologic malignancies, and discuss the potential of these neoantigen...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research

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CONCLUSION: prompt diagnosis, through fundus examination and FA, and proper antiviral therapy were the mainstays to counteract the posterior uveitis. Nowadays, vaccination is a safe weapon to efficaciously reduce the ZVZ incidence among general population. PMID: 32644840 [PubMed - as supplied by publisher]
Source: Ocular Immunology and Inflammation - Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research
CONCLUSION: Ophthalmologists play an important role in a hospital-wide toxicity team and need to include IRAEs in their differential diagnosis. Given new drug development, ophthalmologists may be the first to identify IRAEs. PMID: 32643982 [PubMed - as supplied by publisher]
Source: Ocular Immunology and Inflammation - Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research
Authors: Rocco D, Gregorc V, Della Gravara L, Lazzari C, Palazzolo G, Gridelli C Abstract INTRODUCTION: The development of immune checkpoint inhibitors (ICI) has represented a revolution in the treatment of non-small cell lung cancer (NSCLC) and has established a new standard of care for different settings. However, through adaptive changes, cancer cells can develop resistance mechanisms to these drugs, hence the necessity for novel immunotherapeutic agents. AREAS COVERED: This paper explores the immunotherapeutics currently under investigation in phase I clinical trials for the treatment of NSCLC as monotherap...
Source: Expert Opinion on Investigational Drugs - Category: Drugs & Pharmacology Tags: Expert Opin Investig Drugs Source Type: research
In this report, a total of 860 publications related to TRPM7 were analyzed. Biophysical Journal ranked top for publishing 31 papers. The United States of America had the largest number of publications (320) with a high citation frequency (11,298) and H-index (58). Chubanov V (38 publications) and Gudermann T (38 citations), who from Ludwig Maximilian University of Munich, were the most productive authors and had the greatest co-citation counts. Our study also combined the bibliometric study with a systematic review on TRPM7, highlighting the four research frontiers of TRPM7. This is the first study that demonstrated the tr...
Source: Channels - Category: Molecular Biology Tags: Channels (Austin) Source Type: research
The classes below are what I am planning to take this fall. My cGPA is 3.62 and my sGPA is 3.4. Organic chemistry 1- 3 Biology of cancer- 2 Environmental physiology- 3 Principles of exercise training- 3 I am thinking of taking a biology course rather than the exercise training class. Should I be focused on taking science courses?
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Pre-Medical - MD Source Type: forums
Publication date: Available online 10 July 2020Source: European Journal of Surgical OncologyAuthor(s): Philip H. Pucher, Saqib A. Rahman, Robert C. Walker, Ben L. Grace, Andrew Bateman, Tim Iveson, Andrew Jackson, Charlotte Rees, James P. Byrne, Jamie J. Kelly, Fergus Noble, Timothy J. Underwood
Source: European Journal of Surgical Oncology (EJSO) - Category: Surgery Source Type: research
CONCLUSIONS: Financial and cultural issues were important hindrances to breast cancer screening in African American women. These findings highlight the importance of affordable health care for preventive health services as well as the relevance of culturally embedded issues to health, while the MQS accentuates the need for more rigorous research articles. Breast cancer screening interventions in this population should attend to barriers identified in this review. PMID: 32641257 [PubMed - as supplied by publisher]
Source: Journal of the National Medical Association - Category: General Medicine Tags: J Natl Med Assoc Source Type: research
Publication date: Available online 9 July 2020Source: Diagnostic and Interventional ImagingAuthor(s): R. Rella, E. Bufi, P. Belli, F. Petta, T. Serra, V. Masiello, A.R. Scrofani, R. Barone, A. Orlandi, V. Valentini, R. Manfredi
Source: Diagnostic and Interventional Imaging - Category: Radiology Source Type: research
Publication date: Available online 10 July 2020Source: Social Science &MedicineAuthor(s): Cierra Buckman, Indran C. Liu, Lindsay Cortright, Dmitry Tumin, Salma Syed
Source: Social Science and Medicine - Category: Psychiatry & Psychology Source Type: research
ConclusionsA high intake of fruits and berries and vegetables, in particular leaf vegetables, are associated with a decreased risk of developing AAA.
Source: European Journal of Nutrition - Category: Nutrition Source Type: research
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