The increasing use of shave biopsy for diagnosing invasive melanoma in Australia.

The increasing use of shave biopsy for diagnosing invasive melanoma in Australia. Med J Aust. 2020 Feb 12;: Authors: Byth LA, Byth J PMID: 32049365 [PubMed - as supplied by publisher]
Source: Medical Journal of Australia - Category: General Medicine Tags: Med J Aust Source Type: research

Related Links:

Conclusions: The nanoliposomal PCSK9 vaccine did not adversely affect the growth of melanoma tumour nor the survival of tumour-bearing mice. PMID: 32051723 [PubMed]
Source: Archives of Medical Science - Category: General Medicine Tags: Arch Med Sci Source Type: research
We report how the A375 melanoma cell line changes following CRISPR-Cas9 inactivation of POLK
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Publication date: Available online 13 February 2020Source: Pharmacological ResearchAuthor(s): Swadesh K. Das, Santanu Maji, Stephen L. Wechman, Praveen Bhoopathi, Anjan K. Pradhan, Sarmistha Talukdar, Devanand Sarkar, Joseph Landry, Chunqing Guo, Xiang-Yang Wang, Webster K. Cavenee, Luni Emdad, Paul B. FisherAbstractThe primary cause of cancer-related death from solid tumors is metastasis. While unraveling the mechanisms of this complicated process continues, our ability to effectively target and treat it to decrease patient morbidity and mortality remains disappointing. Early detection of metastatic lesions and approaches...
Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research
Left ventricular ejection fraction decreased was observed in 13.6% of patients treated with BRAF and MEK inhibitors. All patients treated with beta ‐blockers and/or angiotensin converting enzyme inhibitors had a normalization of left ventricular ejection fraction. Half of patients with left ventricular ejection fraction decreased had also ophthalmologic adverse event. AbstractBRAF and MEKis have revolutionized the management of BRAFV600‐mutated melanoma patients. Left ventricular ejection fraction decrease (LVEF‐D) related to these treatments has not been thoroughly evaluated to date. The main objective of this study...
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: ORIGINAL RESEARCH Source Type: research
AbstractIn the past decades, the roles of carbohydrates in living organisms and their potential use in many fields have been extensively investigated. Sialyl Lewis x (sLex), a member of body carbohydrate, is an inherent blood-type tetrasaccharide on the surface of different cells, the lymphocyte, neutrophil, some T cells, multiple tumor cells and so on. SLex is a common ligand of the three selectins, L-selectin, E-selectin and P-selectin, and plays important roles in multiple physiological phenomenas by interacting with selectins. Under normal physiological conditions, sLex can affect the immune process and fertilization p...
Source: Glycoconjugate Journal - Category: Biochemistry Source Type: research
This study aimed to determine the safety, tolerability, and recommended phase II doses of trametinib plus uprosertib (GSK2141795) in patients with solid tumors likely to be sensitive to MEK and/or AKT inhibition.MethodsThis was a phase I, open-label, dose-escalation, and dose-expansion study in patients with triple-negative breast cancer orBRAF-wild type advanced melanoma. The primary outcome of the expansion study was investigator-assessed response. Among 126 enrolled patients, 63 received continuous oral daily dosing of trametinib and uprosertib, 29 received various alternative dosing schedules, and 34 were enrolled into...
Source: Cancer Chemotherapy and Pharmacology - Category: Cancer & Oncology Source Type: research
AbstractAdenosine deaminase acting on RNA 1 (ADAR1) has been shown to participate in the regulation of endothelial cells (ECs), as well as local and systemic inflammatory responses. Here, we find that bacterial lipopolysaccharide (LPS) ‐induced upregulation of ADAR1 in lung ECs is impaired in aged mice, an animal model with high rates of sepsis and mortality. Endothelial cell‐specific ADAR1 knockout (ADAR1ECKO) mice suffer from higher mortality rates, aggravated lung injury, and increased vascular permeability under LPS challenge. In primary ADAR1 knockout ECs, expression of the melanoma differentiation ‐associated g...
Source: FEBS Letters - Category: Biochemistry Authors: Tags: RESEARCH ARTICLE Source Type: research
(Far Eastern Federal University) Scientists from Far Eastern Federal University (FEFU, Russia), University of Geneva (Switzerland), Minjiang University, and Fuzhou University (China) pointed out WDR74 protein playing an important role in lung cancer and melanoma primary tumors/metastases progression. During the research, the artificially gained WDR74 function brought about a high activity in cancer cells. However, when the function had been dropped cells failed to metastasize becoming more vulnerable to chemotherapy. Related articles are published in Cancer Letters and Oncogene.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news
Melanoma can be lethal if not detected early and treated. Early detection can be facilitated via skin self-examination (SSE) and as such, SSE is part of melanoma follow-up care for individuals with a prior his...
Source: BMC Cancer - Category: Cancer & Oncology Authors: Tags: Research article Source Type: research
In melanoma, the lymphocytic infiltrate is a prognostic parameter classified morphologically into 'brisk', 'non-brisk' and 'absent' entailing a functional association that has never been proved. Recently, it has been shown that lymphocytic populations can be very heterogeneous, and that anti-PD-1 immunotherapy supports activated T cells. Here, we characterize the immune landscape in primary melanoma by high-dimensional single cell multiplex analysis in tissue sections (MILAN technique) followed by image analysis, RT-PCR and shotgun proteomics. We observed that the brisk and non-brisk patterns are heterogeneous functional c...
Source: eLife - Category: Biomedical Science Tags: Cancer Biology Source Type: research
More News: Australia Health | General Medicine | Melanoma | Skin Cancer