Interleukin 10: the critical role of a pleiotropic cytokine in food allergy.

Interleukin 10: the critical role of a pleiotropic cytokine in food allergy.
Allergol Immunopathol (Madr). 2020 Feb 08;:
Authors: Nedelkopoulou N, Dhawan A, Xinias I, Gidaris D, Farmaki E
Abstract
Despite advances in research, the pathophysiology of food allergy has not yet been fully elucidated. IL-10 has both a pro- and anti-inflammatory effect on the development of food allergy and in order to understand its different immune-modulatory effects the factors that influence the inflammatory microenvironment need to be taken into account. Specific single nucleotide polymorphisms of the IL-10 gene seem to confer an increased risk of developing food allergy, but to date there is a substantial lack of genome- wide association studies regarding the genetic and epigenetic underpinnings of the disease. Special interest has been drawn to the development of allergen-specific regulatory CD4+CD25+ T-cells secreting IL-10 in the immunotherapy of allergic diseases. In addition, a distinct population of human tolerogenic dendritic cells (DC), DC-10 seems to hold great potential and could potentially serve as a therapeutic tool to improve the management of food allergy.
PMID: 32046867 [PubMed - as supplied by publisher]

Source: Allergologia et Immunopathologia - February 7, 2020 Category: Allergy & Immunology Authors: Nedelkopoulou N, Dhawan A, Xinias I, Gidaris D, Farmaki E Tags: Allergol Immunopathol (Madr) Source Type: research