Graphene Oxide-based Nanocomposite Enabled Highly Efficient Targeted Synergistic Therapy for Colorectal Cancer

Publication date: Available online 12 February 2020Source: Colloids and Surfaces A: Physicochemical and Engineering AspectsAuthor(s): Zhichao Qiu, Jing Hu, Ziwei Li, Xiaoxue Yang, Jun Hu, Qingjun You, Shuo Bai, Yong Mao, Dong Hua, Jian YinAbstractIntegrating different therapies into a single nanoplatform has shown great potential for synergistic anti-tumor therapy. In this work, we fabricated the graphene oxide (GO)-based nanosheets loaded with chemotherapeutic drug 5-fluorouracil (5-FU) and modified with GE11, which is an efficient ligand for epidermal growth factor receptor (EGFR). The nanocomposite system 5-FU/GO-PEG-GE11 was found to transfer 5-FU into EGFR-overexpressing HCT-116 cells effectively. The oxidation of glutathione in the tumor cells was found to be accelerated and then destroy the intracellular redox balance after irradiation.The 5-FU/GO-PEG-GE11 nanocomposites exhibited an enhanced synergistic anti-tumor efficacy both in vitro and in vivo. Tumor inhibition rate was 90% in subcutaneous colorectal cancer (CRC) bearing mouse model. The GO-based nanocomposites serve as a versatile platform integrated of PTT and chemotherapy with EGFR-targeting ability, which hold great promise for CRC treatment.Graphical abstractThe 5-FU/GO-PEG-GE11 nanocomposites provide a versatile platform with EGFR-targeting ability for colorectal cancer treatment, which exhibited enhanced synergistic PTT-based multimodal anti-tumor efficacy in vitro and in vivo.
Source: Colloids and Surfaces A: Physicochemical and Engineering Aspects - Category: Chemistry Source Type: research