More healthcare professionals to be allowed to prescribe

The Medicines and Medical Devices Bill will expand number of prescribers of low-risk medicines to reduce GP workload Related items fromOnMedica Variations in uptake of prescribing guidance impact on patients Antibiotic scrip rates lower in CAM-trained practices Pharmacists could offer high-dose statins direct to patients Clinicians need better options if we are to stop over-medication NI launches ‘One Health’ plan to tackle antimicrobial resistance
Source: OnMedica Latest News - Category: UK Health Source Type: news

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Paradoxically, low serum cholesterol has been associated with increased mortality risk among older adults. How does cholesterol metabolism in older persons differ from that in younger persons?Journal of the American Geriatrics Society
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Internal Medicine Journal Article Source Type: news
Authors: Wójcik C Abstract Atherosclerotic cardiovascular disease (ASCVD) is the main cause of morbidity and mortality in the US. ASCVD is caused by elevated levels of ApoB lipoproteins, which over many years penetrate the arterial subendothelial space leading to plaque growth and eventually rupture causing clinical symptoms. ApoB lipoprotein levels are approximated in clinical practice by LDL-C measurement. LDL-C lowering agents (statins, ezetimibe and PCSK9 inhibitors) reduce cardiovascular risk in primary and secondary prevention proportionally to LDL-C reduction (23% per 1 mmol/L of LDL). However, for a ...
Source: Postgraduate Medicine - Category: Internal Medicine Tags: Postgrad Med Source Type: research
Authors: Wan Q, Qian S, Huang Y, Zhang Y, Peng Z, Li Q, Shu B, Zhu L, Wang M Abstract Cardiovascular disease is the number one cause of human morbidity and mortality worldwide. Although cholesterol-lowering drugs, including statins and recently approved PCSK9 inhibitors, together with antithrombotic drugs have been historically successful in reducing the occurrence of coronary artery disease (CAD), the high incidence of CAD remains imposing the largest disease burden on our healthcare systems. We reviewed cardiovascular drugs recently approved or under clinical development, with a particular focus on their pharmaco...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
Authors: Xu RX, Wu YJ Abstract Coronary artery disease (CAD) is one of the leading causes of death worldwide. It is well known that dyslipidemia is a major pathogenic risk factor for atherosclerosis and CAD, which results in cardiac ischemic injury and myocardial infarction. Lipid-modifying drugs can effectively improve lipid abnormalities including reducing low-density lipoprotein cholesterol (LDL-C) and triglycerides (TG) or increasing high-density lipoprotein cholesterol (HDL-C), and eventually decrease the incidence of cardiovascular events. This chapter will review basic principles of lipid metabolism and focu...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
Nearly half of preventable patient harm was accounted for by drug-related incidents and other treatments Related items fromOnMedica MHRA tightens licence restrictions on valproate for women NI launches ‘One Health’ plan to tackle antimicrobial resistance Antibiotic scrip rates lower in CAM-trained practices GPs defend practice on prescribing statins NHS England in bid to cut drugs waste
Source: OnMedica Latest News - Category: UK Health Source Type: news
ConclusionProteomic analysis pointed to impairment of lipid metabolism as a major change in septic patients secondary to HAP, which was further validated by the reduced levels of cholesterol moieties and apolipoproteins in plasma. Our results stress the involvement of lipids in the pathogenesis of sepsis, which is in accordance with previous reports supporting the role of lipid moieties in pathogen toxin clearance and in modulating inflammatory responses.
Source: Clinical Proteomics - Category: Biochemistry Source Type: research
Conclusion: The genome-wide screen in the yeast deletion library allowed us to identify a large number of host genes required for AaCdtB cytotoxicity. Further investigation could lead to more insights into the mechanisms of CdtB intoxication. Introduction Bacterial pathogens often possess several virulence factors to facilitate colonization and survival in hosts. Cytolethal distending toxin (CDT) is a genotoxin produced by many Gram-negative pathogens, such as Escherichia coli, Aggregatibacter actinomycetemcomitans, Haemophilus ducreyi, Shigella dysenteriae, Helicobacter hepaticus, and Campylobacter species (Gargi ...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Shawna L. Semple1, Tania Rodríguez-Ramos1, Yamila Carpio2, John S. Lumsden3, Mario P. Estrada2* and Brian Dixon1* 1Department of Biology, University of Waterloo, Waterloo, ON, Canada2Center for Genetic Engineering and Biotechnology, Havana, Cuba3Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, ON, Canada Pituitary adenylate cyclase-activating polypeptide (PACAP) is a multifunctional neuropeptide that is widely distributed in mammals and is capable of performing roles as a neurotransmitter, neuromodulator, and vasodilator. This polypeptide belongs to the glucagon/secretin ...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
This article is protected by copyright. All rights reserved. PMID: 30216432 [PubMed - as supplied by publisher]
Source: Clinical and Developmental Immunology - Category: Allergy & Immunology Authors: Tags: Clin Exp Immunol Source Type: research
SPECIAL FROM You may watch what you eat, drink filtered water, and use your seat belt to protect yourself on the road. Yet many health hazards are lurking around us in not-so-obvious places. Here, a few to steer clear of:  1. Scented candles A fragrant candle may help you unwind and de-stress. But burning those containing a chemical calledlimonene, often used for citrus-scented candles, as well as many cleaning products, can produce fumes that are downright unhealthy. Recent British research found that households with a high levels of limonene correlated with high levels of formaldehyde, which irritates the eyes and ...
Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news
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