Sexually Dimorphic DNA-methylation in Cardiometabolic Health: A Systematic Review

Cardiometabolic diseases include cardiovascular diseases (CVD), type 2 diabetes (T2D) and their associated risk factors including components of the metabolic syndrome and obesity[1]. Aging is associated with development of unfavorable cardiometabolic profile which in large contributes to increased incidence of major cardiovascular events and mortality[2]. Intermediate cardiometabolic risk factors are unequally distributed among sexes, and sex differences are also described in cardiometabolic diseases prevalence, clinical characteristics and prognosis[3 –5].
Source: Maturitas - Category: Primary Care Authors: Source Type: research

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Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - Category: Endocrinology Tags: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Source Type: research
Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - Category: Endocrinology Tags: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Source Type: research
Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - Category: Endocrinology Tags: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Source Type: research
Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - Category: Endocrinology Tags: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Source Type: research
nson Metabolic syndrome is a cluster of interrelated conditions that is associated with an increased risk of cardiovascular disease (CVD) and type 2 diabetes mellitus (T2DM). Oxidative stress may impair normal physiological functions, leading to various illnesses. T2DM is considered to be associated with increased oxidative stress, inflammation, and dyslipidemia, which may play a significant role in the development of cardiovascular complications, cancer and vision loss through cataracts and retinopathy. While conventional therapies are a cornerstone for the management of the major risk factors of metabolic syndrome, i...
Source: Molecules - Category: Chemistry Authors: Tags: Review Source Type: research
AbstractDe ‐glucosylation and re‐glucosylation of glycoproteins by glucosidase II and uridine diphosphate‐glucose: glycoprotein glucosyltransferase 1 (UGGT1), respectively, are important steps in glycoprotein quality control. Misfolded glycoprotein accumulation is associated with endoplasmic reticulum st ress and can lead to protein misfolding diseases such as metabolic syndrome. Here, we analyzed the expression and activities of glucosidase II and UGGT1 in rat models of obesity and obese type 2 diabetes, phenotypes associated with moderate and severe metabolic syndrome, respectively. In obesity, th e mRNA and protei...
Source: FEBS Letters - Category: Biochemistry Authors: Tags: RESEARCH LETTER Source Type: research
PREVALENCE OF VITAMIN D DEFICIENCY IN URBAN SOUTH INDIANS WITH DIFFERENT GRADES OF GLUCOSE TOLERANCE. Br J Nutr. 2020 Mar 26;:1-24 Authors: Jayashri R, Venkatesan U, Shanthi Rani CS, Deepa M, Anjana RM, Mohan V, Pradeepa R Abstract The present study assessed the prevalence of vitamin D deficiency in an urban south Indian population in individuals with different grades of glucose tolerance.A total of 1,500 individuals [900 normal glucose tolerance(NGT), 300 prediabetes and 300 with type 2 diabetes mellitus(T2DM)] who were not on vitamin D supplementation were randomly selected from the Chennai Urban Ru...
Source: The British Journal of Nutrition - Category: Nutrition Authors: Tags: Br J Nutr Source Type: research
Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - Category: Endocrinology Tags: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Source Type: research
Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - Category: Endocrinology Tags: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Source Type: research
Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - Category: Endocrinology Tags: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Source Type: research
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