The endoplasmic reticulum-mitochondria encounter structure: coordinating lipid metabolism across membranes.

The endoplasmic reticulum-mitochondria encounter structure: coordinating lipid metabolism across membranes. Biol Chem. 2020 Feb 01;: Authors: Kornmann B Abstract Endosymbiosis, the beginning of a collaboration between an Archaeon and a Bacterium and founding step in the evolution of Eukaryotes, owes its success to the establishment of communication routes between the host and the symbiont to allow the exchange of metabolites. As far as lipids are concerned, it is the host that has learnt the symbiont's language, as eukaryote lipids appear to have been borrowed from the bacterial symbiont. Mitochondria exchange lipids with the rest of the cell at membrane contact sites. In fungi, the Endoplasmic Reticulum-Mitochondria Encounter Structure (ERMES) is one of the best understood membrane tethering complexes. Its discovery has yielded crucial insight into the mechanisms of intracellular lipid trafficking. Despite a wealth of data, our understanding of ERMES formation and its exact role(s) remains incomplete. Here, I endeavour to summarize our knowledge on the ERMES complex and to identify lingering gaps. PMID: 32049644 [PubMed - as supplied by publisher]
Source: Biological Chemistry - Category: Chemistry Tags: Biol Chem Source Type: research