Protective effects of polymethoxyflavone-rich cold-pressed orange peel oil against ultraviolet B-induced photoaging on mouse skin

Publication date: April 2020Source: Journal of Functional Foods, Volume 67Author(s): Guijie Li, Fang Tan, Qunlin Zhang, Anqun Tan, Yujiao Cheng, Qi Zhou, Manjiao Liu, Xiang Tan, Linhua Huang, Russell Rouseff, Houjiu Wu, Xin Zhao, Guolu Liang, Xiaochun ZhaoAbstractThe protective effects of the topical application of orange peel cold-pressed oil (CPO), a rich polymethoxyflavones (PMFs) source, on ultraviolet B (UVB)-induced skin injury were studied. Depilated KM mice were irradiated by UVB at one minimal erythemal dose every day and the treated groups were smeared with CPO before radiation. After two weeks we found that CPO helped to maintain the dermal structure and enhanced serum levels and skin tissue expression of superoxide dismutase, catalase and glutathione peroxidase. In serum CPO lowered interleukin-6/-1β and tumor necrosis factor α levels; in skin it decreased the levels of type III collagen and H2O2 but increased hydroxyproline and type I collagen. Moreover, the skin expression of matrix metalloproteinases 2/9 was downregulated, whereas the expression of tissue inhibitor of metalloproteinases 1/2 was upregulated. The above effects followed a dose-dependent manner. Liquid chromatography analysis of irradiated skin tissue showed partial decomposition of PMFs into 5-hydroxy-PMFs.Graphical abstract

Source: Journal of Functional Foods - February 14, 2020 Category: Nutrition Source Type: research