Effect of Vancomycin or Daptomycin With vs Without an Antistaphylococcal β-Lactam on Mortality, Bacteremia, Relapse, or Treatment Failure in Patients With MRSA Bacteremia: A Randomized Clinical Trial

RCT (n=352) found no significant difference in the primary composite end point of mortality, persistent bacteremia, relapse, or treatment failure for addition of an antistaphylococcal β-lactam to standard antibiotic therapy (vancomycin or daptomycin) vs standard therapy alone.
Source: Current Awareness Service for Health (CASH) - Category: Consumer Health News Source Type: news

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CONCLUSION: High anticipation and vigilance is required to detect concurrent bacteremia in dengue patients. Early recognition of warning signs with readily antibiotic therapy is important to prevent mortality and morbidity in these patients. Our report also highlights the MRSA as a rare cause of thyroid abscess with only 5 cases have been reported in the literature so far. PMID: 32164519 [PubMed - as supplied by publisher]
Source: Infectious Disorders Drug Targets - Category: Infectious Diseases Authors: Tags: Infect Disord Drug Targets Source Type: research
This article summarizes the available evidence enabling a stratification of risk for multidrug-resistant bacteria (MDRB) in patients with skin and soft tissue infection (SSTI). Recent findings MDRB are increasingly reported in both healthcare-associated (HCA) and community-acquired (CA)-SSTI, including in patients with life-threatening presentations for whom early initiation of adequate antimicrobial therapy is pivotal to improve outcomes. Community-associated methicillin-resistant Staphylococcus aureus (MRSA) is now endemic in several geographical areas and may cause outbreaks in frail populations or other at-risk clus...
Source: Current Opinion in Infectious Diseases - Category: Infectious Diseases Tags: SKIN AND SOFT TISSUE INFECTIONS: Edited by Matteo Bassetti Source Type: research
Conclusion. Rapid and accurate detection of S. aureus with the Xpert MRSA/SA BC assay in positive blood culture bottles allowed earlier targeted patient management. Negative Xpert results are suggestive of coagulase negative staphylococci, allowing de-escalation of antimicrobial therapy if clinically appropriate. PMID: 32141812 [PubMed - as supplied by publisher]
Source: Journal of Medical Microbiology - Category: Microbiology Authors: Tags: J Med Microbiol Source Type: research
ConclusionThere was a significant association of antibiotic therapy and age on S. aureus carriage profiles in CF patients indicating that antibiotic therapy prevents acquisition of new clones, while during aging of patients with persisting S. aureus, dominant clones were selected and mutations in the spa-repeat region accumulated.
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Empirical anti-MRSA treatment is associated with an increased risk of 30-day mortality in patients hospitalized for pneumonia, compared with standard antibiotic therapy, according to a retrospective study.Reuters Health Information
Source: Medscape Pathology Headlines - Category: Pathology Tags: Pulmonary Medicine News Source Type: news
US-based cohort study of 88,605 hospitalisations for pneumonia did not find a mortality benefit for treatment with empirical anti –methicillin-resistant S aureus (MRSA) therapy vs standard antibiotics for any group of patients examined, even those with risk factors for MRSA.
Source: Current Awareness Service for Health (CASH) - Category: Consumer Health News Source Type: news
This cohort study compares 30-day mortality among adult patients hospitalized for pneumonia receiving empirical anti –methicillin-resistant Staphylococcus aureus (MRSA) therapy vs standard empirical antibiotic regimens.
Source: JAMA Internal Medicine - Category: Internal Medicine Source Type: research
This randomized trial compares the effect of combining standard antibiotic therapy (intravenous vancomycin or daptomycin) with an antistaphylococcal β-lactam (intravenous flucloxacillin, cloxacillin, or cefazolin) vs standard therapy alone on a composite outcome of mortality, bacteremia, relapse, or treatment failure in adults with methicillin-resistant Staphylococcus aureus (MRSA) bacteremia.
Source: JAMA - Category: General Medicine Source Type: research
This study aimed to determine whether molecular assays could detect genes encoding carbapenemases, ESBL and MRSA, directly from respiratory samples, so as to expedite appropriate therapy and infection control for patients with BLRTI.MethodsThe CRE, ESBL and MRSA/SA ELITe MGB® assays were performed directly on 354 respiratory specimens sampled from 318 patients admitted with BLRTI. Molecular results were compared to routine culture-based diagnostics results.ResultsPositive (PPV) and negative (NPV) predictive values of the CRE ELITe MGB® kit were 75.9% [IC 95%: 60.3-86.7] and 100%, respectively. PPV and NPV of the ES...
Source: Journal of Hospital Infection - Category: Infectious Diseases Source Type: research
Abstract Methicillin-resistant Staphylococcus aureus (MRSA) is considered a common colonizer of burn wound and accounts for high morbidity and mortality all across the globe. Systemic antibiotic therapy which is generally prescribed for these patients has a number of limitations. These include high drug dose, toxicity, and chances of development of drug resistance. However, local delivery of drug not only addresses these limitations but also provides better efficacy at the site of infection. In the present study, hydrogel preparations were developed for the topical delivery of moxifloxacin for the treatment of S. ...
Source: AAPS PharmSciTech - Category: Drugs & Pharmacology Authors: Tags: AAPS PharmSciTech Source Type: research
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