Study Shows No Benefit for Plasma Exchange in ANCA Vasculitis Study Shows No Benefit for Plasma Exchange in ANCA Vasculitis

In findings that raise questions about the go-to treatment for patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis, researchers behind the PEXIVAS study have concluded that plasma exchange does not reduce the odds of death or end-stage kidney disease.Reuters Health Information
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Medscape Today News Source Type: news

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ConclusionIn this large international study, several clinical and laboratory factors were identified as associated with renal involvement in ANCA-associated vasculitis.
Source: Autoimmunity Reviews - Category: Allergy & Immunology Source Type: research
Background: Although an etiology of Kawasaki disease (KD) is unknown, an aberrant innate immune system in predisposed individuals has been proposed to play a key role in the development of KD vasculitis. Various etiological pathogens have been propo...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Burns, Electricity, Explosions, Fire, Scalds Source Type: news
Publication date: Available online 13 February 2020Source: CellAuthor(s): Mandeep Singh, Katherine J.L. Jackson, Jing J. Wang, Peter Schofield, Matt A. Field, David Koppstein, Timothy J. Peters, Deborah L. Burnett, Simone Rizzetto, Damien Nevoltris, Etienne Masle-Farquhar, Megan L. Faulks, Amanda Russell, Divya Gokal, Asami Hanioka, Keisuke Horikawa, Alexander D. Colella, Timothy K. Chataway, James Blackburn, Tim R. MercerSummaryPathogenic autoantibodies arise in many autoimmune diseases, but it is not understood how the cells making them evade immune checkpoints. Here, single-cell multi-omics analysis demonstrates a share...
Source: Cell - Category: Cytology Source Type: research
ConclusionRTX seems to be a safe and useful agent in inducing disease remission and reducing previous immunosuppressive treatment in IgAV pediatric and adult patients resistant or refractory to glucocorticoids or other immunosuppressive drugs, and in those patients in whom these agents are contraindicated. Nevertheless, controlled clinical trials in are still warranted to clarify the role of RTX in IgAV.
Source: Autoimmunity Reviews - Category: Allergy & Immunology Source Type: research
ConclusionsThe majority of patients with PCNSV responded to treatment. We found patient subsets with different outcomes. Mycophenolate mofetil may be an effective alternative to CYC.
Source: Autoimmunity Reviews - Category: Allergy & Immunology Source Type: research
"Fleshy" Skin Cellulitis: A Triggering Factor for ANCA Associated Vasculitis. Acta Med Indones. 2019 Oct;51(4):338-343 Authors: Yang SC, Mustafar R, Kamaruzaman L, Wei Yen K, Mohd R, Cader R Abstract A 59-year-old lady with underlying hypothyroidism presented with acute contact dermatitis progressed to cellulitis with superimposed bacterial infection and acute kidney injury. She responded to initial management with antibiotics, but a week later, she had cutaneous and systemic vasculitis. Her skin biopsy consistent with immune-mediated leuko-cytoclastic vasculitis and her blood test was positi...
Source: Acta medica Indonesiana - Category: Internal Medicine Tags: Acta Med Indones Source Type: research
Zika virus (ZIKV) is highly neurotropic after crossing the placenta, inducing teratogenic effects that result in delayed development and microcephaly in infants. The available evidence for vertical transmission of this infection is based on placental studies showing alterations in trophoblastic tissue. However, complete characterization of ZIKV-infected placenta and involved pathways has yet to be fully clarified. This case report of placental ZIKV infection describes morphologic and molecular changes in the placenta. Hyperplasia of placental Hofbauer cells in chorionic villi and numerous histiocyte-like cells in the decid...
Source: International Journal of Gynecological Pathology - Category: Pathology Tags: Pathology of the Corpus: Case Reports Source Type: research
New England Journal of Medicine,Volume 382, Issue 7, Page 622-631, February 2020.
Source: New England Journal of Medicine - Category: Internal Medicine Authors: Source Type: research
New England Journal of Medicine,Volume 382, Issue 7, Page 671-673, February 2020.
Source: New England Journal of Medicine - Category: Internal Medicine Authors: Source Type: research
We report an additional series of 11 medically refractory cases of presumed or proved reversible cerebral vasoconstriction syndrome successfully treated with intra-arterial verapamil infusion. Furthermore, we propose that the reversal of vasoconstriction, as seen on angiography, could fulfill a diagnostic criterion.
Source: American Journal of Neuroradiology - Category: Radiology Authors: Tags: INTERVENTIONAL Source Type: research
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