Development and Validation of a Scoring System, Based on Genetic and Clinical Factors, to Determine Risk of Steatohepatitis in Asian Patients with Nonalcoholic Fatty Liver Disease

There are no biomarkers of nonalcoholic steatohepatitis (NASH) that are ready for routine clinical use. We investigated whether an analysis of PNPLA3 and TM6SF2 genotypes (rs738409 and rs58542926) can be used to identify patients with nonalcoholic fatty liver disease (NAFLD), with and without diabetes, who also have NASH.

Source: Clinical Gastroenterology and Hepatology - February 12, 2020 Category: Gastroenterology Authors: Bo Kyung Koo, Sae Kyung Joo, Donghee Kim, Seonhwa Lee, Jeong Mo Bae, Jeong Hwan Park, Jung Ho Kim, Mee Soo Chang, Won Kim Source Type: research