Dose-Escalated Radiation Therapy for Pancreatic Cancer: A Simultaneous Integrated Boost Approach

Publication date: Available online 13 February 2020Source: Practical Radiation OncologyAuthor(s): Eugene J. Koay, Alexander N. Hanania, William A. Hall, Cullen M. Taniguchi, Neal Rebueno, Sten Myrehaug, Katharine L. Aitken, Laura A. Dawson, Christopher H. Crane, Joseph M. Herman, Beth EricksonAbstractPurposeTo provide a detailed description of practical approaches to dose-escalation in pancreatic cancer.Materials/MethodsThe current paper represents an international collaborative effort of radiation oncologists from the MR-linac consortium with expertise in pancreatic dose-escalation. A fifteen fraction hypofractionated intensity-modulated radiation therapy [IMRT] (67.5Gy/15fx) and five fraction stereotactic body radiation therapy (SBRT) case (50Gy/5fx) are presented with information regarding patient selection, target volumes, organs-at-risk, dose constraints and specific considerations regarding quality assurance. Additionally, we address barriers to dose-escalation and briefly discuss future directions in dose-escalation for pancreatic cancer, including particle therapy and magnetic-resonance guided radiotherapy (MRgRT).
Source: Practical Radiation Oncology - Category: Cancer & Oncology Source Type: research