Notes from the Field: Carbapenem-resistant Klebsiella pneumoniae with mcr-1 Gene Identified in a Hospitalized Patient - Wyoming, January 2019

In December of 2018, Wyoming identified the state's first case of carbapenem-resistant Enterobacteriaceae (CRE) containing mcr-1, which is a gene that can make bacteria resistant to colistin, a drug that can be the last resort for some multidrug-resistant infections like CRE.
Source: CDC Morbidity and Mortality Weekly Report - Category: American Health Tags: Antibiotic and Antimicrobial Resistance Carbapenem Resistant Enterobacteriaceae (CRE) MMWR Morbidity & Mortality Weekly Report Carbapenem Resistant Enterobacteriaceae CRE Source Type: news

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In this study, 110 selected Aeromonas hydrophila isolates isolated from food, animals, and human clinical material from 2010 to 2015 were analyzed. Antimicrobial susceptibility testing was performed by the disk diffusion method, and polymerase chain reaction was conducted to investigate the virulence genes hemolysin (hlyA), cytotoxic enterotoxin (act), heat-labile cytotonic enterotoxin (alt), aerolysin (aerA), and DNase-nuclease (exu). At least 92.7% of the isolates had one of the investigated virulence genes. Twenty different virulence profiles among the isolates were recognized, and the five investigated virulence genes ...
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
Abstract Antimicrobial-resistant bacteria (ARB) carrying antimicrobial resistance genes (ARGs) have been increasingly detected in water sources. Pseudomonas sp. are opportunistic pathogens commonly reported in water samples and different antimicrobial resistance mechanisms have been described in Pseudomonas sp., producing multidrug-resistant (MDR) phenotype. Besides, the presence of heavy metal resistance genes (HMRGs) may select ARB, which is worrying. Therefore, this study aimed to characterize the genotypes of Pseudomonas sp. isolated from different water sources. Water samples (i.e., rivers, streams, lakes and...
Source: Current Microbiology - Category: Microbiology Authors: Tags: Curr Microbiol Source Type: research
NEW BRUNSWICK, NJ, May 27, 2020 — The Janssen Pharmaceutical Companies of Johnson &Johnson today announced that the U.S. Food and Drug Administration (FDA) has granted approval for a new pediatric formulation of SIRTURO® (bedaquiline). SIRTURO® is now indicated for use as part of combination therapy in the treatment of adult and pediatric patients (5 years and older and weighing at least 15 kg) with pulmonary multidrug-resistant tuberculosis (MDR‑TB). In the U.S., the medicine should be reserved for use when an effective treatment regimen cannot otherwise be provided. This indication received accelera...
Source: Johnson and Johnson - Category: Pharmaceuticals Tags: Innovation Source Type: news
ConclusionsFew strains of NDM-1-PA have been identified worldwide, all belonging to ST235. The combination of ST235 and ExoU is a predictor of highly unfavorable prognosis. The potential spread of these high-risk clones in healthcare settings is worrisome because treatment options are limited. Early identification of high-risk clones could help in outbreaks investigation and infections control.
Source: Antimicrobial Resistance and Infection Control - Category: Infectious Diseases Source Type: research
Publication date: June 2020Source: Journal of Global Antimicrobial Resistance, Volume 21Author(s): Jason Farlow, Maia Nozadze, Nino Mitaishvili, Adam Kotorashvili, Nato Kotoria, Keto Arobelidze, Viktoria Tavadze, Tsiuri Simsive, Paata Imnadze, Nabil Latif, Mikeljon P. Nikolich, Michael Washington, Mary K. Hinkle, Paul Kwon, Nino Trapaidze
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
Publication date: Available online 20 May 2020Source: Journal of Global Antimicrobial ResistanceAuthor(s): Elizabeth Maria Bispo Beltrão, Érica Maria de Oliveira, Crhisllane Rafaele dos Santos Vasconcelos, Adriane Borges Cabral, Antônio Mauro Rezende, Ana Catarina Souza Lopes
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
Serratia marcescens has emerged as an important opportunistic pathogen responsible for nosocomial and severe infections. Here, we determined phenotypic and molecular characteristics of 54 S. marcescens isolates obtained from patient samples from intensive-care-unit (ICU) and neonatal intensive-care-unit (NIUC) of a Brazilian tertiary hospital. All isolates were resistant to beta-lactam group antibiotics, and 92.6% (50/54) were not susceptible to tigecycline. Furthermore, 96.3% showed intrinsic resistance to polymyxin E (colistin), a last-resort antibiotic for the treatment of infections caused by MDR (multidrug-resistant) ...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
ConclusionsRisk of acquiring MDR-E while travelling increases depending on travel destination and if antibiotics are used during travel. This information is useful for the development of guidelines for healthcare facilities with low MDR-E prevalence rates to prevent admission of carriers without appropriate measures. The impact of such guidelines should be assessed.
Source: Antimicrobial Resistance and Infection Control - Category: Infectious Diseases Source Type: research
Publication date: June 2020Source: Journal of Global Antimicrobial Resistance, Volume 21Author(s): Absar Talat, Shamsi Khalid, Hayder Abdul R. Majeed, Asad U. Khan
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
Publication date: Available online 19 May 2020Source: Journal of Global Antimicrobial ResistanceAuthor(s): Yan Yang, Xue Li, Youwen Zhang, Jianhua Liu, Xinxin Hu, Tongying Nie, Xinyi Yang, Xiukun Wang, Congran Li, Xuefu You
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
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