Circulating MicroRNAs as potential biomarkers for monitoring the response to in vivo treatment with rituximab in systemic lupus erythematosus patients

Publication date: Available online 13 February 2020Source: Autoimmunity ReviewsAuthor(s): Irene Cecchi, Carlos Perez-Sanchez, Savino Sciascia, Massimo Radin, Ivan Arias de la Rosa, Nuria Barbarroja Puerto, Luca Scudeler, Laura Perez-Sanchez, Alejandra Maria Patiño Trives, Maria Angeles Aguirre Zamorano, Elisa Menegatti, Dario Roccatello, Chary Lopez-Pedrera
Source: Autoimmunity Reviews - Category: Allergy & Immunology Source Type: research

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Collagen vascular disease, including systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and scleroderma (SSc), all have auto-antibodies in their pathogenesis though the effect after heart transplantation is not known. Our aim was to assess the impact of collagen vascular disease on the risk of post-transplant donor specific antibodies (DSA), rejection, and cardiac allograft vasculopathy (CAV).
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: (598) Source Type: research
Journal of Postgraduate Medicine 2020 66(2):117-117
Source: Journal of Postgraduate Medicine - Category: Internal Medicine Source Type: research
Conclusionα2AP regulates the inflammatory responses through plasmin inhibition and proinflammatory cytokine production and is associated with the development of LN. Our findings may be used to develop a novel therapeutic approach for SLE.
Source: Immunity, Inflammation and Disease - Category: Allergy & Immunology Authors: Tags: ORIGINAL RESEARCH Source Type: research
Interleukin 10 (IL-10) is an antiinflammatory cytokine, but also promotes B cell responses and plays a pathogenic role in systemic lupus erythematosus (SLE). CD4+CCR6+IL-7R+T cells from human tonsils produced IL-10 following stimulation by naïve B cells, which promoted B cell immunoglobulin G (IgG) production. These tonsillar CCR6+B helper T cells...
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Tags: Biological Sciences Source Type: research
AbstractIntroductionSeveral factors have been associated with the development of preeclampsia in women with systemic lupus erythematosus (SLE).ObjectiveTo identify risk factors associated with preeclampsia in patients with SLE and its impact on fetal outcomes.Patients and methodsWe studied a prospective cohort of pregnancies in women with SLE from January 2009 to December 2018. Demographic, clinical, serological and drug use characteristics were compared between patients who developed preeclampsia and those who did not, as well as the main neonatal outcomes. An adjusted logistic regression analysis was performed to identif...
Source: International Journal of Rheumatic Diseases - Category: Rheumatology Authors: Tags: ORIGINAL ARTICLE Source Type: research
ObjectiveGenetic variants in the region of tumor necrosis factor –induced protein 3–interacting protein 1 (TNIP1) are associated with autoimmune disease and reducedTNIP1 gene expression. The aim of this study was to define the functional genetic mechanisms drivingTNIP1 hypomorphic expression imparted by the systemic lupus erythematosus –associatedTNIP1 H1 risk haplotype.MethodsDual luciferase expression and electrophoretic mobility shift assays were used to evaluate the allelic effects of 11 risk variants on enhancer function and nuclear protein binding in immune cell line models (Epstein ‐Barr virus [E...
Source: Arthritis and Rheumatology - Category: Rheumatology Authors: Tags: Original Article Source Type: research
This study aimed to evaluate the factors associated with pregnancy outcomes in patient...
Source: BMC Research Notes - Category: Research Authors: Tags: Research note Source Type: research
Iguratimod, a novel immunomodulatory agent for rheumatoid arthritis, has been shown to be effective against murine lupus. The aim of this study was to make a preliminary evaluation of the efficacy and safety o...
Source: Arthritis Research and Therapy - Category: Rheumatology Authors: Tags: Research article Source Type: research
AbstractThe transcription factor IRF8 (ICSBP) is required for the development and maturation of myeloid cells (dendritic cells, monocytes, macrophages), and for expression of intrinsic anti-microbial function such as antigen capture, processing and presentation to lymphoid cells, and for activation of these cells in response to cytokines and pro-inflammatory stimuli (IFN- γ, IFN-β, LPS).IRF8 deficiency in humans causes a severe primary immunodeficiency presenting as susceptibility to infections, complete or severe depletion of blood dendritic cells (DC) subsets, depletion of CD14+ and CD16+ monocytes and reduced...
Source: Human Genetics - Category: Genetics & Stem Cells Source Type: research
Authors: Zhang Y, Hu M, Wei D, Zhang H, Chu B, Xu HM, Wang T Abstract Both the herpes zoster virus and suid herpesvirus type 1 (SuHV-1) belong to the Varicellovirus genus of the α-herpesviridae subfamily. They may cause opportunistic infections especially in patients with kidney diseases, varying from latent illness to overt lethality. Under these circumstances, impaired renal function is both the culprit for and victim of the infection. However, fulminant eruption of severe skin herpes zoster in lupus nephritis (LN) patients under prolonged immunosuppressive therapy is rare and even more rarely seen is the S...
Source: International Journal of Medical Sciences - Category: Biomedical Science Tags: Int J Med Sci Source Type: research
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