Actinic Keratosis and Cutaneous Squamous Cell Carcinoma.
CONCLUSION: There are many options for the treatment of AK and cSCC that must be considered in the interdisciplinary care of these entities. PMID: 32048593 [PubMed - in process]
Marieke A Peters, Marnix H Geukes Foppen, Christian U Blank, Marianne B CrijnsJournal of Cancer Research and Therapeutics 2020 16(1):170-172 With the discovery of v-Raf murine sarcoma viral oncogene homolog B (BRAF) inhibitors, new treatment possibilities arose against metastatic melanoma. A frequent adverse effect of BRAF inhibitor therapy is the induction of epithelial proliferations such as cutaneous squamous cell carcinoma and verrucous papilloma. Here, we describe a case in which a patient developed extensive anal epithelial proliferations resembling condylomata acuminata, after starting vemurafenib treatment. This a...
Conclusion: Topical combination therapy with imiquimod, 5-FU, and tretinoin with intermittent, brief cryotherapy effectively treated a small, invasive SCC in this select patient who deferred surgery. Prospective randomized-controlled clinical trials to assess the role of combination topical treatment for invasive SCCs are warranted. J Drugs Dermatol. 2020;19(2)202-204. doi:10.36849/JDD.2020.2228 PMID: 32155018 [PubMed - as supplied by publisher]
Background: Actinic keratoses (AKs) are precursor lesions to squamous cell carcinoma that arise from keratinocyte dysplasia. Treatment of AKs has traditionally involved cryotherapy, various topical agents such as topical 5-fluorouracil (5-FU), or combination therapy. Due to irritation with use of topical 5-FU, short-contact therapy 5-FU with cryotherapy has been reported. Vitamin D derivatives have also been reported as systemic anti-cancer agents, though clinical data for usage is limited mainly due to hypercalcemia as a dose-limiting adverse effect.
Introduction: Topical 5-Fluorouracil (5-FU) under zinc oxide occlusion has been reported to be effective in reducing actinic damage and as an adjuvant to surgery for squamous cell carcinomas (SCCs) on diffusely photodamaged skin. It has also been shown to increase patient satisfaction as well as compliance and is tolerable without major side effects. Organ transplant patients are at an increased risk of developing skin cancer due to immunosuppressive medications. 5-FU is frequently prescribed as an at-home field treatment for diffuse actinic keratoses (AKs).
We report a case of squamous cell carcinoma secondary to plantar wart in a 72-year-old Chinese woman. 20 years previously the patient found a 1-cm round grayish yellow plaque on her right heel. The lesion was diagnosed as plantar wart by every dermatologist the patient consulted, and can be gradually subsided after treatment such as cryotherapy and photodynamic therapy, but recurred frequently. 2 years previously the plaque enlarged accompanying with aggravated pain, biopsy indicated verrucous hyperplasia.
We report a case of a patient with multiple lesions of cutaneous squamous cell carcinoma on the lower extremities treated successfully with intralesional 5- fluorouracil. PMID: 30500149 [PubMed - as supplied by publisher]
In conclusion, cryotherapy is an effective and safe method for the treatment of esophageal neoplastic processes, ranging from early stages of low grade dysplasia to esophageal cancer. PMID: 30487696 [PubMed - in process]
Learning Objectives: After studying this article, the participant should be able to: 1. Characterize basal and squamous cell carcinomas as low or high risk based on size, location, histology, and clinical features. 2. Understand appropriate surgical margins in low- and high-risk lesions, and other management options, including Mohs micrographic surgery, electrodissection and curettage, topical agents, cryotherapy, photodynamic therapy, and radiation therapy. 3. Discuss adjuvant therapies for locally advanced and metastatic disease, including radiation therapy, chemotherapy, and targeted therapies such as hedgehog pathway...
Background: A robust qRT-PCR-based noninvasive gene expression test that differentiates primary melanomas from similar looking benign pigmented lesions became available to dermatologists in the U.S. recently. Patient and clinician demand for a similar test to noninvasively differentiate nonmelanoma skin cancers (generally excised) from benign or precursor lesions (generally treated via nonsurgical modalities such as cryotherapy or chemical and immunologic destruction) has been growing.
Publication date: February 2018 Source:Clinical Plasma Medicine, Volume 9, Supplement Author(s): Georg Daeschlein, Claudia Sicher, Sebastian von Podewils, Rico Rutkowski, Michael Jünger Main topics in cancer treatment in dermatology are melanoma (MM), basal cell carcinoma (BCC), squamous cell carcinoma (SCC) and metastatic skin tumors. Thereof stage IV MM because of fatal outcome is uf utmost importance. Despite some substantial therapeutic progress now in this entity by immunologic treatments alternatives are warranted when disease is progressing under therapy or the tumor basically appears refractory. National guid...