Improved and residual functional abnormalities in major depressive disorder after electroconvulsive therapy

Publication date: Available online 12 February 2020Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Jiaojian Wang, Yang Ji, Xuemei Li, Zhengyu He, Qiang Wei, Tongjian Bai, Yanghua Tian, Kai WangAbstractElectroconvulsive therapy (ECT) can induce fast remission of depression but still retain the residual functional impairments in major depressive disorder (MDD) patients. To delineate the different functional circuits of effective antidepressant treatment and residual functional impairments is able to better guide clinical therapy for depression. Herein, voxel-level whole brain functional connectivity homogeneity (FcHo), functional connectivity, multivariate pattern classification approaches were applied to reveal the specific circuits for treatment response and residual impairments in MDD patients after ECT. Increased FcHo values in right dorsomedial prefrontal cortex (dmPFC) and left angular gyrus (AG) and their corresponding functional connectivities between dmPFC and right AG, dorsolateral prefrontal cortex (dlPFC), superior frontal gyrus, precuneus (Pcu) and between left AG with dlPFC, bilateral AG, and left ventrolateral prefrontal cortex in MDD patients after ECT. Moreover, we found decreased FcHo values in left middle occipital gyrus (MOG) and lingual gyrus (LG) and decreased functional connectivities between MOG and dorsal postcentral gyrus (PCG) and between LG and middle PCG/anterior superior parietal lobule in MDD patients before and af...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - Category: Psychiatry Source Type: research