Anatomical And Clinical Implications Of Vagal Modulation Of The Spleen

Publication date: Available online 12 February 2020Source: Neuroscience &Biobehavioral ReviewsAuthor(s): Gabriel S. Bassi, Alexandre Kanashiro, Norberto C. Coimbra, Niccolò Terrando, William Maixner, Luis UlloaAbstractThe vagus nerve coordinates most physiologic functions including the cardiovascular and immune systems. This mechanism has significant clinical implications because electrical stimulation of the vagus nerve can control inflammation and organ injury in infectious and inflammatory disorders. The complex mechanisms that mediate vagal modulation of systemic inflammation are mainly regulated via the spleen. More specifically, vagal stimulation prevents organ injury and systemic inflammation by inhibiting the production of inflammatory cytokines in the spleen. However, the neuronal regulation of the spleen is controversial suggesting that it can be mediated by either monosynaptic innervation of the splenic parenchyma or secondary neurons from the celiac ganglion depending on the experimental conditions. Recent physiologic and anatomic studies suggest that inflammation in infectious and inflammatory disorders is regulated by neuro-immune multi-synaptic interactions between the vagus and the splanchnic nerves to modulate the spleen. Here, we review the current knowledge on these interactions, and discuss their experimental and clinical implications in infectious and inflammatory disorders.
Source: Neuroscience and Biobehavioral Reviews - Category: Neuroscience Source Type: research

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Source: Frontiers in Physiology - Category: Physiology Source Type: research
Condition:   Dysautonomia Interventions:   Procedure: Celiac ganglion block;   Drug: Liposomal bupivacaine Sponsor:   Johns Hopkins University Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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Source: Steroids - Category: Drugs & Pharmacology Source Type: research
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Source: Braz J Med Biol Res - Category: Research Authors: Tags: Braz J Med Biol Res Source Type: research
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Source: Veterinary Research - Category: Veterinary Research Source Type: research
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