Parade of Pathogens in 2014

(MedPage Today) -- Old infectious enemies (measles) and new ones (Chikungunya) caused disease at home and abroad.
Source: MedPage Today Pediatrics - Category: Pediatrics Source Type: news

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nnen Luyten Chikungunya and yellow fever virus cause vector-borne viral diseases in humans. There is currently no specific antiviral drug for either of these diseases. Banana plants are used in traditional medicine for treating viral diseases such as measles and chickenpox. Therefore, we tested selected banana cultivars for their antiviral but also cytotoxic properties. Different parts such as leaf, pseudostem and corm, collected separately and extracted with four different solvents (hexane, acetone, ethanol, and water), were tested for in vitro antiviral activity against Chikungunya virus (CHIKV), enterovirus 71 (E...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research
Vincent and Rich return to the University of Texas Medical Branch at Galveston to speak with Dennis Bente, Shannan Rossi, Nikos Vasilakis, and Scott Weaver about their work on viruses transmitted by mosquitoes and ticks. Hosts: Vincent Racaniello and Rich Condit Guests: Dennis Bente, Shannan Rossi, Nikos Vasilakis, and Scott Weaver Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Measles virus vectored chikungunya vaccine (J Inf Dis) World Reference Center for Emerging Viruses and Arboviruses Insect-specific alphavirus vaccine vect...
Source: This Week in Virology - MP3 Edition - Category: Virology Authors: Source Type: podcasts
nte Murillo Minguito de Ory The aim of this study is to evaluate the performance characteristics of the LIAISON XL Zika Capture IgM II. For this purpose we tested 128 samples obtained from recent infections caused by the Zika (ZIKV; 74 samples), dengue (DENV; 10 samples), chikungunya (CHIK V; 11 samples), rubella (RUBV; 10 samples) and measles (MeV; 10 samples) viruses, as well as human parvovirus B19 (HPVB19; 13 samples). The results of the assay under evaluation are compared with those obtained from an indirect immunofluorescence (IIF) assay, and the discrepancies are resolved by considering other laborator...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research
CONCLUSION: Clinical data, laboratory results, and neuroimaging findings support the diagnosis of encephalitis and the specific viral etiology. To increase the likelihood of etiologic confirmation, it is important to know the best approach to collecting samples and to choose the best identification technique for each virus. The differential diagnosis of viral encephalitis includes other infections and immune-mediated inflammatory central nervous system disorders. PMID: 31513761 [PubMed - as supplied by publisher]
Source: Jornal de Pediatria - Category: Pediatrics Authors: Tags: J Pediatr (Rio J) Source Type: research
ABSTRACT Measles is an acute febrile exanthematic disease of viral etiology, highly contagious, being the cause of morbidity and mortality of children in developing countries, whereas it has become rarer in developed countries due to vaccination. Its differential diagnosis should be made with other childhood viral respiratory diseases such as influenza, rhinovirus and adenovirus, and exanthematic febrile diseases such as rubella, roseola and varicella. In tropical regions, it should be performed with dengue, zika and chikungunya. Its clinical picture presents the following phases: incubation, usually asymptomatic; a prodro...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - Category: Pathology Source Type: research
María Maximina B. Moreno-Altamirano1*, Simon E. Kolstoe2 and Francisco Javier Sánchez-García1* 1Laboratorio de Inmunorregulación, Departamento de Inmunología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Mexico City, Mexico 2School of Health Sciences, University of Portsmouth, Portsmouth, United Kingdom Over the last decade, there has been significant advances in the understanding of the cross-talk between metabolism and immune responses. It is now evident that immune cell effector function strongly depends on the metabolic pathway in w...
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
Conclusions Apart West Nile virus (78), thousands of congenital microcephaly cases, fetal brain tissue damage and neurological syndromes have been associated with ZIKV infection. Unfortunately, the epidemics of this mosquito born, and a relative stable virus is on a rise. Although congenital microcephaly is a rare disorder however, due to lack of standardized diagnostic test facilities, the incidence in the geographically widespread ZIKV epidemic regions is higher. Animals studies showed that ZIKV is a neurotropic virus. It directly targets the developing embryonic brain cells by inducing apoptosis, cell-cycle arrest, and...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Purpose: We have developed a live recombinant measles vector-based vaccine to prevent Chikungunya disease (MV-CHIK). Previously, the safety and immunogenicity was demonstrated in a Phase 1 clinical trial (EudraCT: 2013-001084-23). Here, we will present the final data of a Phase 2 clinical trial in 263 healthy, volunteer adults (NCT02861586). Chikungunya is a rapidly spreading viral disease affecting significant parts of the Americas, India and South East Asia. In the majority of patients, the febrile acute disease turns into a chronic disease causing severe, debilitating arthritis that can last years post-infection.
Source: International Journal of Infectious Diseases - Category: Infectious Diseases Authors: Tags: 21.080 Source Type: research
In 2010, the World Health Assembly set three milestones for measles prevention to be achieved by 2015: 1) increase routine coverage with the first dose of measles-containing vaccine (MCV1) among children aged 1 year to ≥90% at the national level and to ≥80% in every district; 2) reduce global annual measles incidence to less than five cases per million population; and 3) reduce global measles mortality by 95% from the 2000 estimate (1).*
Source: CDC Morbidity and Mortality Weekly Report - Category: American Health Tags: American Indian - Alaska Native Health Animal-Related Diseases Chikungunya Virus Chronic Disease Dengue Fever (DF) Global Health HIV Prevention HIV/AIDS HIV/AIDS and STDs Measles MMWR Morbidity & Mortality Weekly Report Public Source Type: news
Publication date: Available online 5 November 2018Source: The LancetAuthor(s): Emil C Reisinger, Roland Tschismarov, Eckhard Beubler, Ursula Wiedermann, Christa Firbas, Micha Loebermann, Andrea Pfeiffer, Matthias Muellner, Erich Tauber, Katrin RamsauerSummaryBackgroundChikungunya fever is an emerging viral disease and substantial threat to public health. We aimed to assess the safety, tolerability, and immunogenicity of a live-attenuated, measles-vectored chikungunya vaccine (MV-CHIK).MethodsIn this double-blind, randomised, placebo-controlled and active-controlled phase 2 trial, we enrolled healthy volunteers aged 18&ndas...
Source: The Lancet - Category: General Medicine Source Type: research
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