Effect of Hibiscus sabdariffa and Zingiber officinale on the antihypertensive activity and pharmacokinetic of losartan in hypertensive rats.

In conclusion, both the investigated herbs significantly increased the antihypertensive effect and plasma concentration of losartan in L-NAME induced hypertensive rats. The current study predicted that the herb-drug interaction between H. sabdariffa-losartan and Z. officinale-losartan could occur; hence these results in rats may warrant further studies in humans, either in humans or in in vitro human liver microsomes. PMID: 32048541 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/32048541?dopt=Abstract

Source: Xenobiotica - February 11, 2020 Category: Research Authors: Ahad A, Raish M, Bin Jardan YA, Alam MA, Al-Mohizea AM, Al-Jenoobi FI Tags: Xenobiotica Source Type: research