Asymmetric Synthesis of Quaternary α-Trifluoromethyl α-Amino Acids by Ir-Catalyzed Allylation Followed by Kinetic Resolution

Chem. Commun., 2020, Accepted Manuscript DOI: 10.1039/D0CC00845A, CommunicationXi-Shang Sun, Qiu Ou-Yang, Shi-Ming Xu, Xing-Heng Wang, Hai-Yan Tao, Lung Wa Chung, Chun-Jiang Wang A facile access to quaternary α-Trifluoromethyl α-Amino Acids has been developed. This sequential reaction, which involves an Ir-catalyzed asymmetric allylation of α-trifluoromethyl aldimine esters followed by an unprecedented kinetic resolution. The content of this RSS Feed (c) The Royal Society of Chemistry

Source: RSC - Chem. Commun. latest articles - February 13, 2020 Category: Chemistry Authors: Xi-Shang Sun Source Type: research