Mind The Gap - Crossing Borders Study

Conditions:   Emphysema;   COPD;   Hyperinflation Lung Intervention:   Device: Bronchoscopic transparenchymal interlobar fissure closure using Aeriseal Sponsors:   University Medical Center Groningen;   Pulmonx Corporation Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials

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Introduction: Bronchoscopic Lung Volume Reduction (BLVR) with the Zephyr® Valve improves lung function, exercise tolerance and quality of life in hyperinflated emphysema patients with little to no collateral ventilation (CV). Here we report further analysis of the impact of BLVR on patient reported outcomes (PROs) in the LIBERATE Study.Methods: 190 severe heterogeneous emphysema subjects were randomized 2:1 (Zephyr Valve to Standard of Care (SOC)) at 24 centers. Subjects were 53% female and had mean forced expiratory volume (FEV1) 27.4% predicted; Residual Volume 225% predicted; St George’s Respiratory Questionna...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Interventional pulmonology Source Type: research
Conclusions: Preventive therapies are routinely performed after the procedure, but a common consensus is needed to define risk factors, prevent and manage the complications. In addition, we think that it would be more beneficial to use the percentages as per procedures or per patients in the identification of complications.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Interventional pulmonology Source Type: research
We report the role of emphysema heterogeneity on lung function after placement of endobronchial one-way valves – Spiration Valve System (SVS). Patients with severe airflow obstruction, hyperinflation, and severe dyspnea without interlobar collateral ventilation were evaluated for enrollment. 113 subjects received SVS valves. Interlobar emphysema heterogeneity was assessed by high resolution computed tomography (HRCT) and categorized as low (10-25%, n=65) or high (>25%, n=48). Lung function was assessed by FEV1, hyperinflation was defined as the ratio of residual volume / total lung capacity and target lobe volume ...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Interventional pulmonology Source Type: research
Introduction: Bronchoscopic lung volume reduction with endobronchial valves (EBV) has been shown to improve lung function and quality of life (QoL) in emphysema patients with severe hyperinflation. Because of increased mortality rates in surgical LVR, patients with a diffusing capacity (DLCO) lower than 20%pred are often excluded from BLVR-treatment.Aims and Objectives: To explore whether EBV treatment in emphysema patients with a DLCO
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Interventional pulmonology Source Type: research
Smoke-measuring smart shirts, breath sound analyzing algorithms, and smart inhalers pave the way of pulmonology and respiratory care into the future. As the number of patients suffering from asthma, COPD, or lung cancer due to rising air pollution and steady smoker-levels will unfortunately not decrease any time soon, we looked around what technology can do to help both patients and caregivers. The results are breathtaking. Attacks of breathlessness are too common The diseases which pulmonologists and respiratory care specialists attempt to fight are among the most common conditions in the modern world – and t...
Source: The Medical Futurist - Category: Information Technology Authors: Tags: Artificial Intelligence Future of Medicine Health Sensors & Trackers AI asthma cancer cancer treatment care COPD diagnostics inhaler lung lung cancer management medical specialty pulmonology respiratory respiratory care Source Type: blogs
We describe a 66‐year‐old man with severe chronic obstructive pulmonary disease (COPD) who faile d assessments for BLVR because of the inability to perform the carbon monoxide diffusion test but subsequently had EBV deployed to his right upper lobe bronchi for persistent air leak complicating a spontaneous pneumothorax. Afterwards, there was subjective improvement in breathlessness, exercise ca pacity, and reduced frequency of exacerbations requiring hospitalization. Lung function parameters showed marked improvement. This case suggests that patients with compatible spirometric lung volume and computed tomography findi...
Source: Respirology Case Reports - Category: Respiratory Medicine Authors: Tags: Case Report Source Type: research
This article also reviews the potential benefits of EBVs and the associated complications. Although bronchial valves have yielded promising results and are a potentially safer alternative to lung volume reduction surgery, further guidelines are needed to improve patient selection and procedure performance. Myth: In severe emphysema, surgical resection is the only option for lung volume reduction.
Source: Clinical Pulmonary Medicine - Category: Respiratory Medicine Tags: Clinical Myths and Evidence-Based Medicine Source Type: research
Conclusions: CT-derived lobar volume and emphysema quantification using the LungSeg program is efficient and reliable in allowing lobar volume assessment. LungSeg has low inter-user variability and agrees better with plethysmography for COPD assessment in our study.Respiration
Source: Respiration - Category: Respiratory Medicine Source Type: research
(Pulmonx) Eisenhower Health is the first hospital in Southern California to offer a new lung valve treatment for patients with severe COPD/emphysema. The Zephyr Endobronchial Valve treatment represents a major advancement because it is the first minimally invasive procedure to help emphysema sufferers breathe easier without major surgery. Done through a simple bronchoscopy, the valves improve patients' quality of life by allowing them to breathe easier, be less short of breath, and be more active and energetic.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
The results of the randomised controlled trials investigating the bronchoscopic lung volume reduction treatment using endobronchial valves (EBV) are promising, and have led to their inclusion in treatment guidelines, US Food and Drug Administration approval and inclusion in routine care in an increasing number of countries. The one-way valve treatment has advanced and is now a regular treatment option. However, this new phase will lead to new challenges in terms of implementation. We believe that key issues in future research concern advanced patient selection, improved methods for target lobe selection, increased knowledg...
Source: European Respiratory Review - Category: Respiratory Medicine Authors: Tags: COPD and smoking Review Source Type: research
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