Quantification of mitral valve regurgitation by 2D and 3D echocardiography compared with cardiac magnetic resonance a systematic review and meta-analysis

AbstractBy means of systematic literature review and meta-analysis, we compared results of studies examining different echocardiographic methods assessing severity of mitral valve regurgitation volume (MVR) with cardiac magnetic resonance imaging (CMR) as standard reference. A systematic search of electronic databases revealed twenty studies eligible for meta-analysis. Results of 2D- and 3D-trans-thoracic (TTE) and trans-esophageal echocardiographic (TEE) proximal isovelocity surface area (PISA) and volumetric methods were compared with CMR. Mean differences (ml) with 95% limits of agreement (LoA) derived from Bland –Altman tests and correlations coefficients [(R) 95% confidence interval (CI)] were pooled together. Overall 1187 patients [mean age = 59 ± 13 years and 678(57%) males] with primary or secondary mild to severe MVR were included. Comparing all echocardiographic methods with CMR showed an overestimation and moderate agreement with difference and 95% LoA of 8.05(− 3.40, 19.49) ml, R = 0.73(95% CI 0.71–0.76) p <  0.001. 3D-PISA followed by 3D-volumetric methods showed the better agreement with an underestimation of − 3.20(− 12.33, 5.92) ml, R = 0.84(95% CI 0.78–0.89) p <  0.001 and overestimation of 3.73(− 9.17, 16.61) ml, R = 0.90(95% CI 0.87, 0.94) p <  0.001, respectively. 2D-volumetric method showed the poorest agreement with difference and 95% LoA of 23.56(− 4.19, 51.31) ml, R = 0.64(95% CI ...
Source: The International Journal of Cardiovascular Imaging - Category: Radiology Source Type: research