HRT of Menopausal Symptoms After Gynecologic Malignancy HRT of Menopausal Symptoms After Gynecologic Malignancy

This review focuses on the safety of hormone replacement therapy in women with a history of gynecologic cancer who have undergone surgery, chemotherapy, or radiation leading to early menopause.Menopause
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Ob/Gyn & Women ' s Health Journal Article Source Type: news

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ConclusionThe findings revealed the heterogeneity of sexual health among BC patients in China and may guide to identify the high-risk patients and enable early intervention.
Source: Supportive Care in Cancer - Category: Cancer & Oncology Source Type: research
The current life expectancy of females in the United Kingdom is estimated to be 82.9 years [1], and the average age of menopause is 51 years [2]. Women in the UK therefore spend around one-third of their life in the menopausal state. The timing of menopause influences future health outcomes, such that an early age at menopause increases risk of bone fractures and cardiovascular diseases while an increased risk of breast, ovarian and endometrial cancer have been associated with a late onset of menopause [3].
Source: Maturitas - Category: Primary Care Authors: Source Type: research
This study aimed to investigate the associations between total and subclasses of flavonoid and breast cancer risk among Chinese population. This case-control study recruited 1522 eligible breast cancer cases and 1547 frequency-matched control subjects from June 2007 to July 2018 in Guangdong, China. Dietary intake was obtained by face-to-face interview using a validated food frequency questionnaire. Odds ratios and 95% confidence intervals were calculated by multivariable logistic regression models. After adjusting for potential confounders, inverse associations were observed between total flavonoids, anthocyanidins, proan...
Source: European Journal of Cancer Prevention - Category: Cancer & Oncology Tags: Breast cancer Source Type: research
Abstract The health benefits and risks of menopausal hormone therapy among women aged 50-59 years are examined in the Women's Health Initiative randomized, placebo-controlled trials using long-term follow-up data and a parsimonious statistical model that leverages data from older participants to increase precision. These trials enrolled 27,347 healthy post-menopausal women aged 50-79 at 40 U.S. clinical centers during 1993-1998, including 10,739 post-hysterectomy participants in a trial of conjugated equine estrogens, and 16,608 participants with uterus in the trial of these estrogens plus medroxyprogesterone acet...
Source: Am J Epidemiol - Category: Epidemiology Authors: Tags: Am J Epidemiol Source Type: research
Cancer treatments can be damaging to the ovary, with implications for future fertility and reproductive lifespan. There is therefore a need for a biomarker than can usefully provide an assessment of the ovary and its potential for long-term function after cancer treatment, and ideally also be of value pre-treatment, for the prediction of post-treatment function. In this review we assess the value of anti-Müllerian hormone (AMH) in this context. Measurement of AMH at the time of cancer diagnosis has been shown to be predictive of whether or not there will remain some ovarian function post-treatment in women with breast...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
Authors: Piek MW, Postma EL, van Leeuwaarde R, de Boer JP, Bos AME, Lok C, Stokkel M, Filipe M, van der Ploeg IMC Abstract Introduction Thyroid cancer is one of the most common carcinomas diagnosed in adolescents and young adults (AYA), with a rapidly rising incidence over the past three decades. Surgery is the standard treatment for patients with differentiated thyroid carcinoma (DTC), and when indicated, followed by radioactive iodine (RAI) treatment. The aim of this study was to evaluate the possible effects of RAI therapy on ovarian function and fertility in women. Methods The PubMed, Embase and Web of Science ...
Source: Thyroid : official journal of the American Thyroid Association - Category: Endocrinology Tags: Thyroid Source Type: research
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
AbstractPurposeTo examine the association between obesity measured by body mass index (BMI) and waist circumference (WC) according to menopausal status in Korean women.MethodsWe identified 6,467,388 women, using the Korean National Health Insurance System Cohort. Cox-proportional hazard models were used to generate adjusted hazard ratios (aHRs) and 95% confidence intervals (CIs) for breast cancer risk in relation to BMI and WC.ResultsIn postmenopausal women, the risk of breast cancer increased with BMI. Compared to women with a BMI of 18.5 –23 kg/m two, the risk of invasive breast cancer was lower in patients with BMI 
Source: Breast Cancer Research and Treatment - Category: Cancer & Oncology Source Type: research
In this issue of the Journal, a group of distinguished Nordic researchers, led by Anne Helene Garde and including four of our Associated Editors, present a discussion paper that originated from a workshop and provides detailed recommendations on night shift work (1). The recommendations are very clear: to protect workers ’ health, night shift schedules should have: (i) ≤3 consecutive night shifts; (ii) shift intervals of ≥11 hours; and (iii) ≤9 hours shift duration. For pregnant women, night work should be limited to one shift per week. The authors acknowledge that under circumstances allowing better possibi...
Source: Scandinavian Journal of Work, Environment and Health - Category: Occupational Health Tags: Editorial Source Type: research
Background: In PALOMA-3, endocrine therapy (ET)-sensitive (ie, documented clinical benefit from prior ET or 2 y adjuvant ET before recurrence) pts with HR+/HER2 – ABC and disease progression on prior ET derived overall survival (OS) benefit from palbociclib (PAL) + fulvestrant (FUL) vs placebo (PBO)+FUL. In pts who received prior chemotherapy (CT) for ABC, median (m)OS was similar between treatment arms, suggesting that prior CT impacts the benefit of PAL +FUL. This post hoc analysis reports OS and progression-free survival (PFS) in the ITT and ET-sensitive populations from PALOMA-3 with/without prior CT for ABC and ...
Source: European Journal of Cancer - Category: Cancer & Oncology Authors: Tags: PROFFERED PAPER SESSION: Proffered Paper Session Source Type: research
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