"Fleshy" Skin Cellulitis: A Triggering Factor for ANCA Associated Vasculitis.
"Fleshy" Skin Cellulitis: A Triggering Factor for ANCA Associated Vasculitis. Acta Med Indones. 2019 Oct;51(4):338-343 Authors: Yang SC, Mustafar R, Kamaruzaman L, Wei Yen K, Mohd R, Cader R Abstract A 59-year-old lady with underlying hypothyroidism presented with acute contact dermatitis progressed to cellulitis with superimposed bacterial infection and acute kidney injury. She responded to initial management with antibiotics, but a week later, she had cutaneous and systemic vasculitis. Her skin biopsy consistent with immune-mediated leuko-cytoclastic vasculitis and her blood test was positive for cytoplasmic-anti-neutrophil cytoplasmic antibody (c-ANCA). A diagnosis of ANCA-associated vasculitis was made and she was treated with immunosuppressant with plasmapheresis and hemodialysis support for her kidney failure. Despite aggressive measures, the patient succumbed to her illness. This case report demonstrates that soft tissue infection could trigger the development of ANCA-associated vasculitis whilst a background of hypothyroidism serves as a predisposing factor as both condition were reported separately in a couple of case studies before. PMID: 32041918 [PubMed - in process]
Conclusions: Results indicate that maternal thyroid conditions are associated with increased ASD risk in progeny, but suggestively not due to direct effects of thyroid hormones. Instead, factors that influence maternal thyroid function could have etiologic roles in ASD through pathways independent of maternal gestational thyroid hormones and thus be unaffected by medication treatment. Factors known to disrupt thyroid function should be examined for possible involvement in ASD etiology.
Conclusion: Based on new research, we recommend the 2017 ATA Guidelines be updated to recommend against treating thyroid antibody-negative women diagnosed with subclinical hypothyroidism in the second trimester or later; to reflect new, moderate-quality evidence supporting the treatment of thyroid peroxidase antibody-negative women with elevated thyroid stimulating hormone levels in the first trimester or earlier; and to recommend against treatment of euthyroid, thyroid peroxidase antibody-positive women undergoing assisted reproductive technology. Transitioning to a Dynamic ATA Guidelines would allow for these and future ...
Memo to senior London doctors points to damage virus can do to other organs and strain on intensive care
Whether or not the mortality finding is real, one expert says, in any case, levothyroxine doesn't make older patients with subclinical hypothyroidism feel any better, so is unwarranted.Medscape Medical News
Outset Medical announced that it received FDA 510(k) clearance for its Tablo Hemodialysis System to be used in the home, expanding its existing labeled indication for use in acute and chronic care facilities. Touted by Outset as a “dialysis ...
Nature Reviews Nephrology, Published online: 06 April 2020; doi:10.1038/s41581-020-0280-yPatients on haemodialysis or peritoneal dialysis are likely to be at increased risk of novel coronavirus disease (COVID-19). Preventive strategies must be implemented to minimize the risk of disease transmission in dialysis facilities, including education of staff and patients, screening for COVID-19 and separation of infected or symptomatic and non-infected patients.
AbstractPurposePrevious studies have demonstrated handwriting changes in patients with overt hyperthyroidism due to Graves ’ disease. The aim of the present study was to investigate handwriting features in patients affected by overt autoimmune hypothyroidism.MethodsThirty subjects – 24 females and 6 males, mean and median age of 50.15 ± 16.8 years and 52.5 years, respectively – with overt hypothyroidism (OH) related to Hashimoto’s thyroiditis (Group 1), and 30 age- and sex-matched euthyroid individuals (Group 2) were recruited to write a “standard text”.Group 1 patie...
Dietary potassium restrictions in kidney disease are complex to follow and may reduce quality of life. However, details on this impact are sparse. We therefore sought to explore patients ’ perspectives on the experienced impact of following low-potassium diets, to inform clinical practice and research.
Conclusion: Gut microbiota composition and function are associated with CKD severity. And, specific gut microbes are potentially helpful for CKD early diagnosis and prognosis monitoring. PMID: 32241215 [PubMed - as supplied by publisher]
CONCLUSIONS: Our results do not support an influence of IL17A on the pathogenesis of IgAV. PMID: 32242803 [PubMed - as supplied by publisher]