A predictive CD8+ T cell phenotype for T1DM progression

Nature Reviews Endocrinology, Published online: 12 February 2020; doi:10.1038/s41574-020-0330-3In a cross-sectional study of individuals with type 1 diabetes mellitus, those who were designated to be slow disease progressors had an increased proportion of autoreactive, islet-specific CD8+ T cells expressing an ‘exhausted’ phenotype. By contrast, rapid disease progressors had increased numbers of islet-specific CD8+ T cells with a transitional memory phenotype.
Source: Nature Reviews Endocrinology - Category: Endocrinology Authors: Source Type: research