A Comparative Study of the Antioxidant and ACE Inhibitory Activities of Selected Herbal Extracts

Publication date: Available online 11 February 2020Source: Journal of Herbal MedicineAuthor(s): Neha Chaudhary, Latha Sabikhi, Shaik Abdul Hussain, Sathish Kumar M HAbstractSome herbal bioactives possess high antioxidant and angiotensin converting enzymes (ACE) inhibition activity, which affects blood pressure levels. Herbal bioactives promote health benefits via different molecular mechanisms and most of these mechanisms are yet to be fully elucidated. In the present study, health promoting potential of aqueous extracts of six herbs viz. Allium sativum L., Withania somnifera (L.) Dunal, Ocimum sanctum L., Hibiscus sabdriffa L., Ginkgo biloba L. and Emblica officinalis at different concentrations (50 to 10,000 µg/mL) were assessed through their antioxidant and ACE inhibitory potential. Results showed that the DPPH (2, 2-diphenyl-1-picrylhydrazyl) activity of the six different herbs ranged from 1.58 ± 0.63 to 11.39 ± 0.15 mM/mL trolox equivalent and was in the order of Emblica officinalis>Withania somnifera>Hibiscus sabdriffa>Ginkgo biloba>Ocimum sanctum =Allium sativum at 1000 µg/mL concentration. Emblica officinalis had IC50 value 180.35 ± 1.17 µg/mL. The corresponding observation for the herb with 2, 2'-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) was 167.19 ± 1.04 µg/mL. Ferric reducing antioxidant power (FRAP) values were significantly higher for Emblica officinalis than the other herbs, and varied from 1.78 ± 0.08 to 2...
Source: Journal of Herbal Medicine - Category: Complementary Medicine Source Type: research