A phase II study of the combination of gemcitabine and imatinib mesylate in pemetrexed-pretreated patients with malignant pleural mesothelioma

Malignant pleural mesothelioma (MPM) is highly aggressive neoplasm, with a median survival of
Source: Lung Cancer - Category: Cancer & Oncology Authors: Source Type: research

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The U.S. Environmental Protection Agency released an asbestos draft risk evaluation Monday that found serious health dangers to workers in the chloralkali industry, the country’s last remaining user of raw asbestos. There is an “unreasonable risk to workers, occupational non-users, consumers and bystanders” the EPA found when evaluating several asbestos products still being imported and used today. The draft risk evaluation was an initial review of asbestos by the EPA under the amended Toxic Substances Control Act (TSCA). “It is being disseminated for peer review purposes and is not final,” an...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Source Type: news
Authors: van Zandwijk N, Reid G, Frank AL Abstract Introduction: Asbestos, the most frequent cause of occupational cancer, continues to be consumed on a massive scale, with millions of people exposed on a daily basis. This review explains why we have failed in curtailing the silent epidemic of asbestos-related disease and why the numbers of asbestos victims are likely to remain high. Emerging and developed countries have to be reminded that asbestos exposure has yet to become a problem of the past. The worldwide spread of asbestos, followed by the surge of asbestos-related cancers, resembles the lung cancer epidemi...
Source: Expert Review of Anticancer Therapy - Category: Cancer & Oncology Tags: Expert Rev Anticancer Ther Source Type: research
Abstract The post‑translational modification of proteins by ubiquitinating enzymes plays a central role in a number of cellular functions, such as cell proteolysis, DNA repair, and cell signaling and communication. Deubiquitinating enzymes (DUBs) disassemble ubiquitin chains and remove ubiquitin moieties from proteins. Targeting DUBs in cancer models has revealed an important role for these enzymes in tumorigenesis, and they therefore have emerged as attractive therapeutic targets. In the present study, the effects of three DUB inhibitors, PR‑619, RA‑9 and LDN‑91946, on a non‑small cell lung cancer cell ...
Source: International Journal of Oncology - Category: Cancer & Oncology Authors: Tags: Int J Oncol Source Type: research
The authors regret that one author ’s name was written incorrectly, being S. Prince instead of S. Austin. It has been corrected in this corrigendum.
Source: Lung Cancer - Category: Cancer & Oncology Authors: Tags: Corrigendum Source Type: research
The Florida Legislature has passed a bill designed to better protect its firefighters from cancer-causing contaminants, including toxic asbestos. By approving the legislation, Florida joined a growing number of states that have passed laws in recent years to help firefighters combat occupational hazards they face every day. The Firefighter Cancer Decontamination Equipment Grant Program in Florida will provide funding for departments to procure supplies, equipment and add additional training that should reduce exposure to hazardous pollutants. It includes all fire departments across the state, from large municipal entities...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Source Type: news
Conditions:   Thoracic Cancer;   Non-small Cell Lung Cancer;   Small-cell Lung Cancer;   Pleural Mesothelioma Intervention:   Other: eRAPID online symptom monitoring in lung cancer Sponsors:   University of Leeds;   The Leeds Teaching Hospitals NHS Trust;   Iqvia Pty Ltd Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Raw asbestos imported to the United States dropped significantly in 2019, according to the recently released U.S. Geological Survey Mineral Commodity Summaries report. The U.S. imported an estimated 100 metric tons of asbestos last year. It’s the smallest amount since records were first kept in 1910, long before the mineral became a major part of the construction industry in America. That number is in sharp contrast to the 681 metric tons imported in 2018. All imported asbestos went to the chloralkali industry — for the second consecutive year — to use in the manufacturing of semipermeable diaphragms for ...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Source Type: news
ConclusionsThis study indicated that CT ‐707 is clinically effective as a new antitumor drug for Chinese lung adenocarcinoma patients with ALK rearrangement. It is safe and reliable and the dose‐expansion phase recruitment has started.
Source: Thoracic Cancer - Category: Cancer & Oncology Authors: Tags: ORIGINAL ARTICLE Source Type: research
The U.S. Food and Drug Administration found asbestos-contaminated talc in nine of the 52 cosmetic products tested during its year-long study released this week. The products with asbestos were recalled at various times throughout the past year when individual results were obtained and the public was notified. Monday’s announcement by the FDA was labeled a Constituent Update and Final Report. It also included those products that showed no trace of contamination. AMA Analytical Services Inc. in Lanham, Maryland, performed all testing for the FDA, using polarized light microscopy and transmission electron microscopy, cu...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Source Type: news
Three of the country’s leading cancer centers have opened a collaborative clinical trial that potentially could change surgical treatment of mesothelioma. Researchers will measure the safety and efficacy of using two different immunotherapy drug regimens — Opdivo (nivolumab) and Yervoy (ipilimumab) — beginning 42 days before surgery. The hope is that at least one will make surgical resection more effective. Sidney Kimmel Cancer Center at Johns Hopkins University, MD Anderson Cancer Center at the University of Texas and Greenebaum Cancer Center at the University of Maryland are working together to enroll a...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Source Type: news
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