Influence of tumor shape and location in eye plaque brachytherapy dosimetry

A common treatment planning technique for eye plaque brachytherapy is to model the tumor as an ellipse. For posterior tumors near the optic disc and fovea, this approach may lead to overlap between tumor and the organ at risk (OAR). We hypothesized that a superior plan can be generated by modeling the actual tumor shape.
Source: Brachytherapy - Category: Cancer & Oncology Authors: Source Type: research

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Conclusion In patients with LACC, hysterectomy is an option in the presence of a central residual tumor after CRT. However, the risk of grades 3 and 4 complications of performed surgery is high. The presence of macroscopic tumor in the pathology specimen and positive surgical margins are poor prognostic factors. The goal of the surgeon should be to achieve a negative surgical margin. It does not seem important if the surgery is simple or radical.
Source: Revista Brasileira de Ginecologia e Obstetricia - Category: OBGYN Source Type: research
AbstractBackgroundTumor marker screening may be useful to evaluate tumor response and detect tumor recurrence. However, usefulness and cut-off value of squamous-cell carcinoma antigen (SCC-Ag) for recurrence and survival has not yet established in cervical cancer.MethodsFrom January 2010 to October 2016, 304 patients with cervical squamous-cell carcinomas with FIGO stage IB-IVA who underwent curative chemoradiotherapy followed by brachytherapy at four institutions were included in this study. Serum SCC-Ag level was measured before treatment, re-measured after completion of treatment, and again at the time of relapse during...
Source: International Journal of Clinical Oncology - Category: Cancer & Oncology Source Type: research
ConclusionFive-year local control and disease-specific survival rates of patients surgically treated for vaginal non-SCC were favorable. Therefore, surgery could be a safe and reasonable option for early-stage primary vaginal non-SCC.
Source: International Journal of Clinical Oncology - Category: Cancer & Oncology Source Type: research
We would like to thank van der Steen and colleagues for their comments on our recently published paper “Long-term Survival and Complications Following Bladder-Preserving Brachytherapy in Patients With cT1-T2 Bladder Cancer” [1]. Undisputedly, the Arnhem group did extremely important pioneering work in the field of brachytherapy for bladder cancer, both open and robot-assisted. In our paper, we de scribed the long-term results achieved with both the open implantation as well as the robot-assisted laparoscopic approach (RAL), which do support the results previously published by van der Steen et al.
Source: Radiotherapy and Oncology - Category: Radiology Authors: Tags: Letter to the Editor Source Type: research
The purpose of this study was to discuss the merits of using depth-sensing infrared camera technology in the brachytherapy operating room during interstitial brachytherapy for gynecologic malignancies.
Source: Brachytherapy - Category: Cancer & Oncology Authors: Source Type: research
Conditions:   Endometrial Cancer;   Brachytherapy;   Quality of Life Interventions:   Other: Tapered applicator;   Other: Standard applicator Sponsor:   Yale University Not yet recruiting
Source: - Category: Research Source Type: clinical trials
Abstract Retinoblastomas represent 6% of all malignant tumors in children under 5 years old, which untreated lead to blindness in the affected eye and death due to metastases. The main symptoms are leukocoria and strabismus, which if possible, always necessitate a clarification within 1 week for exclusion of a retinoblastoma. The most frequent differential diagnoses are Coats' disease and persistent fetal vasculature (PFV) as well as other intraocular tumors, in particular astrocytomas. Systemic chemotherapy, if necessary in combination with laser hyperthermia, local chemotherapy and brachytherapy are the most imp...
Source: Der Ophthalmologe - Category: Opthalmology Authors: Tags: Ophthalmologe Source Type: research
Men with Gleason grade Group (GG) 4 and 5 prostate cancer have high failure rates when treated by conventional therapy. We investigated the effect of higher radiation doses on freedom from biochemical failure (FBF) and prostate cancer mortality (cause-specific survival [CSS]) in men treated with a combination of permanent implant and external beam irradiation (EBRT).
Source: Brachytherapy - Category: Cancer & Oncology Authors: Source Type: research
High dose-rate (HDR) brachytherapy is commonly administered as a boost to external beam radiation therapy (EBRT). Our purpose was to compare toxicity with increasingly hypofractionated EBRT in combination with a single 15  Gy HDR boost for men with intermediate-risk prostate cancer.
Source: Brachytherapy - Category: Cancer & Oncology Authors: Source Type: research
Authors: ChicheĊ‚ A PMID: 32190076 [PubMed]
Source: Journal of Contemporary Brachytherapy - Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research
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