Transcriptomic Features of T Cell-Barren Tumors Are Conserved Across Diverse Tumor Types

Conclusions: This study presents the first evidence that solid tumors of diverse anatomical origin acquire conserved transcriptional alterations that may be operative in the T cell-cold state. Our findings demonstrate the potential clinical utility of CD8-Low tumor-associated genes for predicting patient immunotherapy outcomes and point to novel mechanisms with potential for broad therapeutic exploitation.
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research