Factors associated with the need for pulmonary valve replacement in asymptomatic patients with isolated pulmonary regurgitation after repair of tetralogy of Fallot: a cardiac magnetic resonance study.
CONCLUSIONS: The RV/LV ratio and PRF had a significant association with the need for PVR in asymptomatic patients with isolated moderate-to-severe PR after TOF repair. PMID: 32041929 [PubMed - as supplied by publisher]
Conclusion: PRP treats ONFH mainly through three mechanisms: inducing angiogenesis and osteogenesis to accelerate bone healing, inhibiting inflammatory reactions in necrotic lesions, and preventing apoptosis induced by glucocorticoids. In addition, as an adjunctive therapy for core decompression, the use of PRP is recommended to improve the treatment of early-stage ONFH patients, especially when combined with stem cells and bone grafts, by inducing osteogenic activity and stimulating the differentiation of stem cells in necrotic lesions. PMID: 32219128 [PubMed - as supplied by publisher]
ConclusionsMiddle to distal ureteral injuries occurring during urologic and gynecologic surgeries can be repaired by the techniques demonstrated in this video manuscript.
ConclusionTypes of endoprosthesis might affect differently on physiological changes and its accommodated risk factors after surgery.
Publication date: Available online 29 March 2020Source: CytotherapyAuthor(s): Helena Debiazi Zomer, Talita da Silva Jeremias, Buddy Ratner, Andrea Goncalves Trentin
Authors: Ma Y, Chen P, Drisko JA, Khabele D, Godwin AK, Chen Q Abstract The promise of poly(ADP-ribose) polymerase inhibitors (PARPis) in the management of epithelial ovarian cancer (EOC) is hampered by the limited clinical activity against BRCA wild-type or homologous recombination-proficient EOC. In order to decrease the resistance and increase the efficacy of PARPis, combination treatments of pharmacological ascorbate and PARPis in preclinical BRCA wild-type EOC models were investigated. The cytotoxicity of pharmacological ascorbate, olaparib and veliparib in a panel of BRCA1/2 wild-type EOC cell lines were meas...
Publication date: Available online 28 March 2020Source: The Annals of Thoracic SurgeryAuthor(s): Stevan S. Pupovac, Jonathan M. Hemli, Karthik Seetharam, Ashley T. Giammarino, S Jacob Scheinerman, Alan R. Hartman, Derek R. Brinster
Publication date: 1 August 2020Source: Chemical Engineering Journal, Volume 393Author(s): Huachu Wu, Liang Shen, Zhu Zhu, Xusong Luo, Yishu Zhai, Xiaobin Hua, Shicheng Zhao, Lian Cen, Zhibing Zhang
This study, for the first time, shows that transplantation of non-autologous mitochondria from healthy skeletal muscle cells into normal cardiomyocytes leads to short-term improvement of bioenergetics indicating "supercharged" state. However, over time these improved effects disappear, which suggests transplantation of mitochondria may have a potential application in settings where there is an acute stress. Outlining Some of the Science Behind Partial Reprogramming at Turn.bio https://www.fightaging.org/archives/2020/03/outlining-some-of-the-science-behind-partial-reprogramming-at-turn-bio/ Tur...
Pediatric straddle injury is a common cause of genital trauma in girls. Most straddle injuries occur between ages 2 and 6 and involve the external genitalia, vestibule, perineum or posterior fourchette. It is important for OBGYN physicians to be trained to manage a pediatric patient with a straddle injury. There are no current tools available to teach the examination and repair of pediatric straddle injuries, however printed 3D models have been used in other areas of medical education. Three- dimensional printing can develop a surgical model that has the same tactile feel as normal tissue.
Transverse Vaginal Septums (TVS) are congenital, obstructive anomalies of the female genital tract typically presenting with abdominal pain and amenorrhea around menarche. Currently, the literature surrounding surgical management is scarce and poorly described. As well, both early and long term postoperative complications are common owing to the complexity of the surgical repair. Lastly, often these patients require intensive vaginal dilation schedules postoperatively, the details and outcomes of which are poorly described.