Excess salt intake promotes M1 microglia polarization via a p38/MAPK/AR-dependent pathway after cerebral ischemia in mice.

In conclusion, HSD promotes polarization in pro-inflammatory M1 microglia by upregulating the expression of the AR protein via p38/MAPK, thereby exacerbating the development of ischemia stroke.
PMID: 32044667 [PubMed - as supplied by publisher]

Source: International Immunopharmacology - February 6, 2020 Category: Allergy & Immunology Authors: Zhang T, Wang D, Li X, Jiang Y, Wang C, Zhang Y, Kong Q, Tian C, Dai Y, Zhao W, Jiang M, Chang Y, Wang G Tags: Int Immunopharmacol Source Type: research