Assessment of a Bayesian Vitrea CT Perfusion Analysis to Predict Final Infarct and Penumbra Volumes in Patients with Acute Ischemic Stroke: A Comparison with RAPID ADULT BRAIN

CONCLUSIONS: Compared with RAPID, the Vitrea default setting was noninferior for patients with interventions and superior in penumbra estimation for patients without interventions as indicated by mean infarct differences and correlations with final infarct volumes.
Source: American Journal of Neuroradiology - Category: Radiology Authors: Tags: ADULT BRAIN Source Type: research

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In the emergency setting of acute ischemic stroke, seizures have been reported in up to 4% of patients. In the absence of arterial occlusion, seizures may also cause abnormalities in CT perfusion in 78% of cas...
Source: BMC Neurology - Category: Neurology Authors: Tags: Case report Source Type: research
AbstractThe role of hyperosmolar therapy (HT) in large hemispheric ischemic or hemorrhagic strokes remains a controversial issue. Past and current stroke guidelines state that it represents a reasonable therapeutic measure for patients with either neurological deterioration or intracranial pressure (ICP) elevations documented by ICP monitoring. However, the lack of evidence for a clear effect of this therapy on radiological tissue shifts and clinical outcomes produces uncertainty with respect to the appropriateness of its implementation and duration in the context of radiological mass effect without clinical correlates of ...
Source: Neurocritical Care - Category: Neurology Source Type: research
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Source: Neurology Today - Category: Neurology Tags: For Your Patients Source Type: research
Prompt and effective management of acute ischemic stroke in the emergency setting requires a high level of suspicion and accurate diagnosis. Conversely, identifying stroke mimics can be challenging, given the similarity of their clinical symptomatology, the necessary rapid assessment and triage, and the overall frenetic pace inherent in the goal of rapid thrombolysis ( “time is brain”).
Source: The Journal of Emergency Medicine - Category: Emergency Medicine Authors: Tags: Selected Topics: Emergency Radiology Source Type: research
AbstractMitochondrial dysfunction has a recognised role in the progression of Alzheimer's disease (AD) pathophysiology. Cerebral perfusion becomes increasingly inefficient throughout ageing, leading to unbalanced mitochondrial dynamics. This effect is exaggerated by amyloid β (Aβ) and phosphorylated tau, two hallmark proteins of AD pathology. A neuroprotective role for the adipose‐derived hormone, leptin, has been demonstrated in neuronal cells. However, its effects with relation to mitochondrial function in AD remain largely unknown. To address this question, we h ave used both a glucose‐serum deprived (CGSD...
Source: Journal of Neurochemistry - Category: Neuroscience Authors: Tags: ORIGINAL ARTICLE Source Type: research
Authors: Xu SY, Li ZX, Wu XW, Li L, Li CX Abstract Todd's paralysis, a neurological abnormality characterized by temporary limb weakness or hemiplegia, typically occurs following a seizure, without enduring consequences. Since limb weakness or hemiplegia can also be a common symptom of an acute ischemic stroke, it is often difficult to diagnose Todd's paralysis in individuals experiencing an acute ischemic stroke if they do not have a pre-existing history of epilepsy. Given that there is a limited understanding of Todd's paralysis, this review discusses the history, prevalence, clinical manifestations, duration, et...
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
AbstractPurposeThere is increasing use of automated computed tomography perfusion (CTP) to aid thrombectomy decision in emergent large vessel occlusion. It is important to understand the performance of these software packages in predicting ischemic core and tissue-at-risk in the real-world setting. The aim of this study was to evaluate whether ischemic core on non-contrast CT (NCCT) and automated CTP correspond and predict infarct extent after thrombectomy for ischemic stroke.MethodsConsecutive patients with acute anterior circulation large vessel occlusion undergoing successful thrombectomy (TICI  2b/3) were studied....
Source: Clinical Neuroradiology - Category: Neurology Source Type: research
In conclusion, common comorbidities in swine result in CMD, in the absence of appreciable atherosclerosis, which is severe en ough to produce perturbations in myocardial oxygen balance, particularly during exercise, resembling key features of INOCA.
Source: Basic Research in Cardiology - Category: Cardiology Source Type: research
Publication date: March 2020Source: Journal of Vascular and Interventional Radiology, Volume 31, Issue 3, SupplementAuthor(s): R. Wang, K. Chang, H. Zhou, J. Wu, G. Cohan, M. Jayaraman, R. Huang, J. Boxerman, L. Yang, F. Hui, J. Woo, H. Bai
Source: Journal of Vascular and Interventional Radiology - Category: Radiology Source Type: research
The risk of stroke in aortic arch (AA) surgery remains a serious concern, despite modern surgical techniques and strategies for cerebral protection. Brain perfusion during AA surgery faces embolic and global ischemic threats, from manipulation and crossclamping of the aorta to malperfusion due to incomplete protective perfusion during the circulatory arrest phase of the operation. Intraoperative diagnosis of stroke can be a challenge, and there are no current standard guidelines for intraoperative neuromonitoring (IONM).
Source: The Journal of Thoracic and Cardiovascular Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: Commentary Source Type: research
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