From Hendra to Wuhan: what has been learned in responding to emerging zoonotic viruses

Publication date: Available online 11 February 2020Source: The LancetAuthor(s): Lin-Fa Wang, Danielle E Anderson, John S Mackenzie, Michael H Merson
Source: The Lancet - Category: General Medicine Source Type: research

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SUMMARY: When preparing for the coronavirus disease 2019 pandemic and its effects on the CNS, radiologists should be familiar with neuroimaging appearances in past zoonotic infectious disease outbreaks. Organisms that have crossed the species barrier from animals to humans include viruses such as Hendra, Nipah, Severe Acute Respiratory Syndrome, and influenza, as well as bacteria and others. Brain CT and MR imaging findings have included cortical abnormalities, microinfarction in the white matter, large-vessel occlusion, and features of meningitis. In particular, the high sensitivity of diffusion-weighted MR imaging in det...
Source: American Journal of Neuroradiology - Category: Radiology Authors: Tags: ADULT BRAIN Source Type: research
(University of Adelaide) University of Adelaide researchers have found that South Australia's population of Grey-headed flying foxes, which took up residence in 2010, has been exposed to a number of viruses, including Hendra virus that can be transmitted to humans via horses. But they have not found evidence of exposure to Australian bat lyssavirus.
Source: EurekAlert! - Biology - Category: Biology Source Type: news
Research in the last decade has uncovered many new paramyxoviruses, airborne agents that cause epidemic diseases in animals including humans. Most paramyxoviruses enter epithelial cells of the airway using sialic acid as a receptor and cause only mild disease. However, others cross the epithelial barrier and cause more severe disease. For some of these viruses, the host receptors have been identified, and the mechanisms of cell entry have been elucidated. The tetrameric attachment proteins of paramyxoviruses have vastly different binding affinities for their cognate receptors, which they contact through different binding s...
Source: Journal of Biological Chemistry - Category: Chemistry Authors: Tags: JBC Reviews Source Type: research
Cedar virus (CedV) is a bat-borne henipavirus related to Nipah virus (NiV) and Hendra virus (HeV), zoonotic agents of fatal human disease. CedV receptor-binding protein (G) shares only ∼30% sequence identity with those of NiV and HeV, although they can all use ephrin-B2 as an entry receptor. We demonstrate that...
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Tags: Biological Sciences Source Type: research
by Dan Lu, Kefang Liu, Di Zhang, Can Yue, Qiong Lu, Hao Cheng, Liang Wang, Yan Chai, Jianxun Qi, Lin-Fa Wang, George F. Gao, William J. Liu Bats harbor many zoonotic viruses, including highly pathogenic viruses of humans and other mammals, but they are typically asymptomatic in bats. To further understand the antiviral immunity of bats, we screened and identified a series of bat major histocompatibility complex (MHC) I Ptal-N*01:01– binding peptides derived from four different bat-borne viruses, i.e., Hendra virus (HeV), Ebola virus (EBOV), Middle East respiratory syndrome coronavirus (MERS-CoV), and H17N10 influenz...
Source: PLoS Biology: Archived Table of Contents - Category: Biology Authors: Source Type: research
Nadine Krüger The Ghana virus (GhV) is phylogenetically related to the zoonotic henipaviruses Nipah (NiV) and Hendra virus. Although GhV uses the highly conserved receptor ephrin-B2, the fusogenicity is restricted to cell lines of bat origin. Furthermore, the surface expression of the GhV attachment glycoprotein (G) is reduced compared to NiV and most of this protein is retained in the endoplasmic reticulum (ER). Here, we generated truncated as well as chimeric GhV G proteins and investigated the influence of the structural domains (cytoplasmic tail, transmembrane domain, ectodomain) of this protein on the intrac...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research
A recent outbreak of Nipah virus (NiV) in India has caused 17 deaths among people living in districts of Kerala state. Its zoonotic nature as well as high rate of human-to-human transmission has led researchers worldwide to work high for understanding the different aspects of the NiV. We performed a codon usage analysis based on publicly available nucleotide sequences of NiV and its host adaptation along with other members of genus Henipavirus in ten hosts. NiV genome encodes nine open reading frames; and overall, no significant bias in codon usage was observed. Aromaticity of proteins had no impact on codon usage. An anal...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
This study investigated the presence of Henipa- and related viruses in the Egyptian Rousette bat in South Africa as well as determining potential excretion in urine over time.
Source: International Journal of Infectious Diseases - Category: Infectious Diseases Authors: Tags: 19.007 Source Type: research
Purpose: Hendra virus is a zoonotic pathogen which was first identified in 1994 and spillover events in horses were sporadic in Queensland (QLD) and New South Wales (NSW), Australia until 2010. The predominant differences during 2011-2017 were the number of spillover events (46 incidents during 2011-2017 compared to 14 incidents during 1994-2010), the unprecedented number of incidents in NSW (19 incidents during 2011-2017 compared to one incident during 1994-2010) and the geographic clustering in southeast QLD and northern NSW (30 incidents in southeast QLD and north NSW compared to 16 incidents in central and northern QLD during 2011-2017).
Source: International Journal of Infectious Diseases - Category: Infectious Diseases Authors: Tags: 03.013 Source Type: research
Publication date: February 2019Source: Current Opinion in Virology, Volume 34Author(s): Lin-Fa Wang, Danielle E AndersonIn the last two decades, several high impact zoonotic disease outbreaks have been linked to bat-borne viruses. These include SARS coronavirus, Hendra virus and Nipah virus. In addition, it has been suspected that ebolaviruses and MERS coronavirus are also linked to bats. It is being increasingly accepted that bats are potential reservoirs of a large number of known and unknown viruses, many of which could spillover into animal and human populations. However, our knowledge into basic bat biology and immuno...
Source: Current Opinion in Virology - Category: Virology Source Type: research
More News: General Medicine | Hendra Virus | Zoonoses