Endocrine disruptors and thyroid autoimmunity

Publication date: Available online 11 February 2020Source: Best Practice & Research Clinical Endocrinology & MetabolismAuthor(s): Salvatore Benvenga, Giusy Elia, Francesca Ragusa, Sabrina Rosaria Paparo, Mattia Maria Sturniolo, Silvia Martina Ferrari, Alessandro Antonelli, Poupak FallahiAbstractMany papers evaluated the effect of the environmental, or occupational endocrine disruptors (ED), on the thyroid gland, that can lead to thyroid autoimmunity. A higher prevalence of “autoimmune thyroid diseases” (AITD) was observed in people living in polluted areas near to petrochemical plants, and in petrochemical workers, but also in area contaminated with organochlorine pesticides, or with polychlorinated biphenyls, or near aluminum foundries. The exposure to Hg in chloralkali workers, or in swordfish consumers has been also found to increase AITD prevalence. Vanadium has been shown to increase the inflammatory response of thyrocytes. A beneficial effect of omega-3 fatty acids, and of myo-inositol and selenomethionine have been shown to counteract the appearance of AITD in subjects exposed to environmental or occupational ED.More large studies are needed to investigate the potential roles of ED in the induction of AITD, and of agents or habits that are able to prevent them.
Source: Best Practice and Research Clinical Endocrinology and Metabolism - Category: Endocrinology Source Type: research