A Relative Bioavailability Study of Two Misoprostol Formulations Following a Single Oral or Sublingual Administration

ConclusionThe relative bioavailability between Angusta and Cytotec could not be confirmed as being equal at the 25 µg or 50 µg level because the 90% CI-values when comparing the ratios for AUC, AUC(0−t), and Cmax were wider than accepted. The reason for this could be the real-life, non-standardized circumstances in which the study was conducted. Sublingual administration seems to have higher bioavailability than oral administration. More studies are needed to ascertain an optimal dosage regime balancing both safety and efficacy for mother and child.Clinical Trial Registrationwww.ClinicalTrials.gov, identifier NCT02516631.
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research