Pharmacodynamics and metabonomics study of Tianma Gouteng Decoction for treatment of spontaneously hypertensive rats with liver-yang hyperactivity syndrome

ConclusionsTGD exhibited the antihypertensive activity at the frequency of administration twice a day, which had the association with RAAS system and mediated 15 biomarkers by regulating metabolisms of glycerol phospholipid, sphingomyelin, energy and amino acid.Graphical abstract
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research

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Our study utilized a murine bleomycin model of pulmonary hypertension (PH) to study the hypothesis that platelets from mice with PH circulate in an activated state and that circulating and lung platelet ‐derived factors, as well as the number of platelets in the lungs of neonatal mice with PH, is significantly increased. Through an extensive characterization of the functional status of platelets from bleomycin‐treated mice, we demonstrate that mice with bleomycin‐induced PH exhibit qualitativ e but not quantitative platelet changes. Circulating platelets from mice with PH exhibit hyperactivity as measured directly by...
Source: Physiological Reports - Category: Physiology Authors: Tags: ORIGINAL RESEARCH Source Type: research
Paroxysmal sympathetic hyperactivity (PSH) has predominantly been described after traumatic brain injury (TBI), which is associated with hyperthermia, hypertension, tachycardia, tachypnea, diaphoresis, dystonia (hypertonia or spasticity), and even motor fe...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Ergonomics, Human Factors, Anthropometrics, Physiology Source Type: news
Our study utilized a murine bleomycin model of pulmonary hypertension (PH) to study the hypothesis that platelets from mice with PH circulate in an activated state and that circulating and lung platelet ‐derived factors, as well as the number of platelets in the lungs of neonatal mice with PH, is significantly increased. Through an extensive characterization of the functional status of platelets from bleomycin‐treated mice, we demonstrate that mice with bleomycin‐induced PH exhibit qualitativ e but not quantitative platelet changes. Circulating platelets from mice with PH exhibit hyperactivity as measured directly by...
Source: Physiological Reports - Category: Physiology Authors: Tags: ORIGINAL RESEARCH Source Type: research
Conclusion: The findings demonstrate that afferent fibers contribute to the maintenance of arterial hypertension and reduced renal function that are likely to be mediated by increased sympathetic nerve activity to the renal territory as well as to other target organs in CKD.
Source: Journal of Hypertension - Category: Cardiology Tags: ORIGINAL PAPERS: Treatment Source Type: research
Paroxysmal sympathetic hyperactivity (PSH) has predominantly been described after traumatic brain injury (TBI), which is associated with hyperthermia, hypertension, tachycardia, tachypnea, diaphoresis, dystonia (hypertonia or spasticity), and even motor features such as extensor/flexion posturing. Despite the pathophysiology of PSH not being completely understood, most researchers gradually agree that PSH is driven by the loss of the inhibition of excitation in the sympathetic nervous system without parasympathetic involvement. Recently, advances in the clinical and diagnostic features of PSH in TBI patients have reached a...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
This article reviews the anatomic, functional, and neurochemical organization of the sympathetic and parasympathetic outputs; the effects on target organs; the central mechanisms controlling autonomic function; and the pathophysiologic basis for core symptoms of autonomic failure. RECENT FINDINGS Functional neuroimaging studies have elucidated the areas involved in central control of autonomic function in humans. Optogenetic and other novel approaches in animal experiments have provided new insights into the role of these areas in autonomic control across behavioral states, including stress and the sleep-wake cycle. SU...
Source: CONTINUUM: Lifelong Learning in Neurology - Category: Neurology Tags: REVIEW ARTICLES Source Type: research
Bioelectronic medicine could be one of healthcare’s biggest secrets. The space is filled with applications – but many aren’t mainstream yet. A panel titled “ Bioelectronic Medicine: Redefining Medical Treatment,” will be held Tuesday, February 11, from 2:05 to 3:00 p.m. in Room 210A at MD&M West Anaheim to discuss the space and how it could impact healthcare. While there have been some significant movements in that time – perhaps one of the greatest has developments has been GlaxoSmithKline teaming up with Verily Lif...
Source: MDDI - Category: Medical Devices Authors: Tags: Digital Health Electronics Source Type: news
Abstract A Rho-associated coiled-coil kinase (ROCK) is identified as a critical downstream effector of GTPase RhoA which contains two isoforms, ROCK1 (also known as p160ROCK and ROKβ) and ROCK2 (also known as Rho-kinase and ROKα), the gene of which is placed on chromosomes 18 (18q11.1) and 2 (2p24), respectively. ROCKs have a principal function in the generation of actin-myosin contractility and regulation of actin cytoskeleton dynamics. They represent a chief role in regulating various cellular functions, such as apoptosis, growth, migration, and metabolism through modulation of cytoskeletal actin synt...
Source: Immunology Letters - Category: Allergy & Immunology Authors: Tags: Immunol Lett Source Type: research
CONCLUSIONS: SAS and cardiological management in patients presenting with myocardial dysfunction should be combined. It is necessary to pursue the scientific investigations with the aim of determining a precise care pathway and the respective places of each of the cardiological and pulmonary measures. PMID: 31866122 [PubMed - as supplied by publisher]
Source: Revue des Maladies Respiratoires - Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research
Publication date: Available online 13 December 2019Source: Biochimica et Biophysica Acta (BBA) - BiomembranesAuthor(s): Juan Francisco Bada Juarez, Juan C. Muñoz-García, Rosana Inácio dos Reis, Alistair Henry, David McMillan, Marco Kriek, Martyn Wood, Catherine Vandenplas, Zara Sands, Luis Castro, Richard Taylor, Anthony WattsAbstractDopamine receptors (DRs) are class A G-Protein Coupled Receptors (GPCRs) prevalent in the central nervous system (CNS). These receptors mediate physiological functions ranging from voluntary movement and reward recognition to hormonal regulation and hypertension. Drugs tar...
Source: Biochimica et Biophysica Acta (BBA) Biomembranes - Category: Biochemistry Source Type: research
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