The anti-inflammatory effects of Pseudorlaric acid D on atherosclerosis

In this study, atherosclerosis model was established by feeding with a high-fat diet in ApoE−/− mice. PLAD was administered intragastrically at a dose of 5 mg/kg for four weeks. We found that PLAD could significantly improve the lipid metabolism and decrease atherosclerotic lesion areas as well as mitigate atherosclerotic changes on vessel walls. Besides, PLAD could markedly inhibit the inflammatory response by down-regulating the levels of Ly6Chi monocytes and NETs, and restraining NETs formation. The expression of pro-inflammatory cytokines IL-1β and IL-18 was also evidently reduced by PLAD. These results indicated that modulating the activation and recruitment of Ly6Chi monocytes and NETs could be the potential anti-inflammatory mechanisms of PLAD on atherosclerosis. PLAD might be a promising therapeutic strategy for the treatment of atherosclerosis and inflammation-related diseases.
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research